Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173238
Abstract: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) play a crucial role in the pathogenesis of RA. RA-FLS display passive pro-inflammatory responses and self-directed aggressive responses, such as pro-inflammatory mediator production, reduced apoptosis and formation of a… read more here.
Keywords: jak; stat signaling; role; peficitinib ... See more keywords
Efficacy and safety of peficitinib in rheumatoid arthritis
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DOI: 10.1080/14397595.2020.1794103
Abstract: Abstract Peficitinib is a Janus kinase (JAK) inhibitor, newly developed and approved in Japan. In contrast to other JAK inhibitors, it is a unique pan-JAK inhibitor, demonstrating inhibition of all JAKs. In patients with rheumatoid… read more here.
Keywords: jak; efficacy safety; safety peficitinib; rheumatoid arthritis ... See more keywords
AB0492 Jak-inhibition with peficitinib and filgotinib in fibroblast-like synoviocytes in rheumatoid arthritis
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DOI: 10.1136/annrheumdis-2018-eular.2182
Abstract: Background With the approval of the Janus kinase inhibitors (JAKi) Tofacitinib and Baricitinib for the treatment of rheumatoid arthritis (RA) in the European Union (EU), the opportunities for a successful therapy were extended by a… read more here.
Keywords: peficitinib filgotinib; tofacitinib baricitinib; hour; rheumatoid arthritis ... See more keywords
Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib
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DOI: 10.3389/fimmu.2019.00541
Abstract: Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient… read more here.
Keywords: rasf; rheumatoid arthritis; peficitinib; synovial fibroblasts ... See more keywords