Polyethylene Glycol‐Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103672
Abstract: Protein therapeutics, except for antibodies, have a short plasma half‐life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. In… read more here.
Keywords: glycol; drug; polyethylene glycol; peg antibodies ... See more keywords
Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.
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DOI: 10.1016/j.chembiol.2019.02.001
Abstract: Biopharmaceuticals have become increasingly attractive therapeutic agents and are often PEGylated to enhance their pharmacokinetics and reduce their immunogenicity. However, recent human clinical trials have demonstrated that administration of PEGylated compounds can evoke anti-PEG antibodies.… read more here.
Keywords: peg antibodies; anti peg; inhibit anticoagulant; activity pegylated ... See more keywords
Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine
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DOI: 10.1101/2022.01.08.22268953
Abstract: Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle mRNA vaccines for SARS-CoV-2 contain small amounts of PEG but it is not known if PEG antibodies are enhanced… read more here.
Keywords: peg antibodies; anti peg; peg; lipid nanoparticle ... See more keywords