Genetic predisposition to PEG‐asparaginase hypersensitivity in children treated according to NOPHO ALL2008
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DOI: 10.1111/bjh.15660
Abstract: Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase (PEG-asparaginase) hampers anti-neoplastic efficacy. Patients with PEG-asparaginase hypersensitivity have been shown to possess zero asparaginase enzyme activity. Using this… read more here.
Keywords: hypersensitivity; asparaginase hypersensitivity; peg asparaginase; enzyme activity ... See more keywords
The association of age and adverse events of PEG‐asparaginase in a pediatric tertiary care hospital; a retrospective review
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DOI: 10.1111/ejh.13867
Abstract: Pediatric patients have a better survival rate for lymphoid malignancies than adolescents and young adult patients (AYA) and current evidence suggests that asparaginase plays a role in improved response to treatment. This study aimed to… read more here.
Keywords: association age; peg asparaginase; age adverse; tertiary care ... See more keywords
The impact of early PEG-asparaginase discontinuation in young adults with ALL: a post hoc analysis of the CALGB 10403 study
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DOI: 10.1182/bloodadvances.2022007791
Abstract: Key points • Early PEG-asparaginase discontinuation is common in young adults with ALL treated with pediatric-inspired regimens• Early PEG-asparaginase discontinuation may lead to inferior survival in young adults with standard-risk ALL read more here.
Keywords: peg asparaginase; young adults; early peg; asparaginase discontinuation ... See more keywords