Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06726-7
Abstract: Human granulocyte colony-stimulating factor (GCSF) is a well-known cytokine for neutropenia treatment. However, daily injections are required due to the short circulating half-life of the protein. To overcome this bottleneck, we fused GCSF with the… read more here.
Keywords: gcsf; peg gcsf; stimulating factor; factor gcsf ... See more keywords
Process Development for Production and Purification of PEGylated RhG-CSF Expressed in Escherichia Coli.
Sign Up to like & getrecommendations! Published in 2022 at "Protein and peptide letters"
DOI: 10.2174/0929866529666220126100559
Abstract: BACKGROUND AND OBJECTIVE Recombinant human granulocyte-colony stimulating factor (rhG-CSF) and its PEGylated form (PEG-GCSF) are used in the cancer therapy. Thus the development of a more cost-effectively method for expressing rhG-CSF and the PEGylation optimization… read more here.
Keywords: purification; csf; rhg csf; peg gcsf ... See more keywords