HBV Antigen‐Guided Switching Strategy From Nucleos(t)ide Analogue to Interferon: Avoid Virologic Breakthrough and Improve Functional Cure
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70021
Abstract: Little is known for factors associated with virologic breakthrough (VBT) after switching from nucleos(t)ide analogue (NA) to pegylated interferon alpha (Peg‐IFN‐α) for patients with chronic hepatitis B (CHB). Eighty patients who received 48‐week Peg‐IFN‐ɑ and… read more here.
Keywords: hbv; peg ifn; hbcrag log10u; nucleos ide ... See more keywords
A pharmacovigilance study of adverse events associated with polycythemia vera treatments using the FDA Adverse Event Reporting System (FAERS) database
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DOI: 10.1007/s00277-025-06480-1
Abstract: Cytoreductive therapies remain vital to the management of polycythemia vera (PV). Real-world data are needed to complement clinical trial safety information. We evaluated the safety profiles of four commonly used PV therapies—ropeginterferon alfa-2b (ropeg, on-label),… read more here.
Keywords: ropeg; peg ifn; ruxolitinib; adverse event ... See more keywords
Consequences and impacts of PEG-IFNα2a shortage: first lessons from a MPN French center
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DOI: 10.1007/s00277-025-06510-y
Abstract: Between March to December 2024, we observed a PEG-IFNα2a shortage in France for MPN patients. We identified and followed 90 patients from our center and observed 80% of difficulties obtaining the drug, and 61 patients… read more here.
Keywords: peg ifn; ifn shortage; drug; center ... See more keywords
Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2016.12.006
Abstract: BACKGROUND AND AIM Toll-like receptor 8 (TLR8) plays an important role in controlling chronic viral infections. However, the role of TLR8 in chronic hepatitis B virus (HBV) infection is poorly understood. In this study, we aimed to… read more here.
Keywords: hbv infection; expression; therapy; expression function ... See more keywords
Efficacy and safety of pegylated interferon alfa-2b in moderate COVID-19: A phase II, randomized, controlled, open-label study
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DOI: 10.1016/j.ijid.2021.03.015
Abstract: Objective To evaluate the efficacy and safety of pegylated interferon alfa-2b (PEG IFN-α2b) along with the standard of care (SOC) in subjects with moderate COVID-19. Methods In this phase 2, randomized, open-label study, adult subjects… read more here.
Keywords: ifn plus; moderate covid; plus soc; day ... See more keywords
Hepcidin expression levels involve efficacy of pegylated interferon-α treatment in hepatitis B-infected liver.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108641
Abstract: BACKGROUND Hepcidin is the master iron regulator hormone produced by the liver. The association of serum hepcidin with pegylated interferon therapy in patients with chronic hepatitis C infection has been studied. However, the role of… read more here.
Keywords: expression; pegylated interferon; hepcidin; treatment ... See more keywords
Real-world anti-viral treatment decisions among chronic hepatitis C patients in Taiwan: The INITIATE study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2018.10.020
Abstract: BACKGROUND/PURPOSE While direct-acting antiviral regimens have been approved for chronic hepatitis C (CHC) patients in Taiwan, reimbursement is limited to certain populations. Thus, pegylated interferon plus ribavirin (PEG-IFN/RBV) remains the standard of care for many… read more here.
Keywords: hepatitis; treatment; ifn rbv; peg ifn ... See more keywords
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.
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DOI: 10.1053/j.gastro.2017.10.017
Abstract: BACKGROUND & AIMS NVR3-778 is a capsid assembly modulator in clinical development. We determined the in vivo antiviral efficacy and effects on innate and endoplasmic reticulum (ER) stress responses of NVR3-778 alone or in combination with… read more here.
Keywords: dna; hbv rna; hbv; nvr3 778 ... See more keywords
The remodeling of B-cell subsets was correlated with the clearance of hepatitis B antigen during pegylated IFN α-2a therapy in CHB patients
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DOI: 10.1080/07853890.2025.2463569
Abstract: Abstract Background B-cell may participate in the cellular immune process of hepatitis B antigen clearance. However, the function and specific mechanism of B-cell during interferon-pegylated interferon α-2a (Peg-IFN-α) treatment in chronic hepatitis B (CHB) patients… read more here.
Keywords: peg ifn; ifn treatment; cell; clearance ... See more keywords
Effectiveness of Pegylated Interferon Alpha-2a in Post-Uveitic Macular Edema Previously Responding to Non-Pegylated Interferon.
Sign Up to like & getrecommendations! Published in 2023 at "Ocular immunology and inflammation"
DOI: 10.1080/09273948.2023.2195494
Abstract: PURPOSE To evaluate the efficacy of pegylated interferon (PEG-IFN) alpha-2a to treat post-uveitic relapsing macular edema (ME) after withdrawal of non-PEG IFN alpha-2a or 2b to maintain treatment efficacy. METHODS This retrospective study investigated subjects… read more here.
Keywords: peg ifn; pegylated interferon; alpha; interferon ... See more keywords
Peripheral Circulating Exosomal-miRNAs Potentially Mediate the Sensitivity to Interferon Treatment in Chronic Hepatitis B Virus Patients.
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DOI: 10.1089/vim.2022.0130
Abstract: Pegylated interferon alfa-2b (Peg-IFN α-2b), a first-line treatment for hepatitis B virus (HBV) infection, can significantly achieve HBsAg clearance in clinic. However, only 30-40% of patients had achieved HBsAg clearance after Peg-IFN α-2b administration. The… read more here.
Keywords: sensitivity; therapy; hepatitis virus; exosomal mirnas ... See more keywords