Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2016.12.006
Abstract: BACKGROUND AND AIM Toll-like receptor 8 (TLR8) plays an important role in controlling chronic viral infections. However, the role of TLR8 in chronic hepatitis B virus (HBV) infection is poorly understood. In this study, we aimed to… read more here.
Keywords: hbv infection; expression; therapy; expression function ... See more keywords
Efficacy and safety of pegylated interferon alfa-2b in moderate COVID-19: A phase II, randomized, controlled, open-label study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.03.015
Abstract: Objective To evaluate the efficacy and safety of pegylated interferon alfa-2b (PEG IFN-α2b) along with the standard of care (SOC) in subjects with moderate COVID-19. Methods In this phase 2, randomized, open-label study, adult subjects… read more here.
Keywords: ifn plus; moderate covid; plus soc; day ... See more keywords
Hepcidin expression levels involve efficacy of pegylated interferon-α treatment in hepatitis B-infected liver.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108641
Abstract: BACKGROUND Hepcidin is the master iron regulator hormone produced by the liver. The association of serum hepcidin with pegylated interferon therapy in patients with chronic hepatitis C infection has been studied. However, the role of… read more here.
Keywords: expression; pegylated interferon; hepcidin; treatment ... See more keywords
Real-world anti-viral treatment decisions among chronic hepatitis C patients in Taiwan: The INITIATE study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2018.10.020
Abstract: BACKGROUND/PURPOSE While direct-acting antiviral regimens have been approved for chronic hepatitis C (CHC) patients in Taiwan, reimbursement is limited to certain populations. Thus, pegylated interferon plus ribavirin (PEG-IFN/RBV) remains the standard of care for many… read more here.
Keywords: hepatitis; treatment; ifn rbv; peg ifn ... See more keywords
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.10.017
Abstract: BACKGROUND & AIMS NVR3-778 is a capsid assembly modulator in clinical development. We determined the in vivo antiviral efficacy and effects on innate and endoplasmic reticulum (ER) stress responses of NVR3-778 alone or in combination with… read more here.
Keywords: dna; hbv rna; hbv; nvr3 778 ... See more keywords
Effectiveness of Pegylated Interferon Alpha-2a in Post-Uveitic Macular Edema Previously Responding to Non-Pegylated Interferon.
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DOI: 10.1080/09273948.2023.2195494
Abstract: PURPOSE To evaluate the efficacy of pegylated interferon (PEG-IFN) alpha-2a to treat post-uveitic relapsing macular edema (ME) after withdrawal of non-PEG IFN alpha-2a or 2b to maintain treatment efficacy. METHODS This retrospective study investigated subjects… read more here.
Keywords: peg ifn; pegylated interferon; alpha; interferon ... See more keywords
Peripheral Circulating Exosomal-miRNAs Potentially Mediate the Sensitivity to Interferon Treatment in Chronic Hepatitis B Virus Patients.
Sign Up to like & getrecommendations! Published in 2023 at "Viral immunology"
DOI: 10.1089/vim.2022.0130
Abstract: Pegylated interferon alfa-2b (Peg-IFN α-2b), a first-line treatment for hepatitis B virus (HBV) infection, can significantly achieve HBsAg clearance in clinic. However, only 30-40% of patients had achieved HBsAg clearance after Peg-IFN α-2b administration. The… read more here.
Keywords: sensitivity; therapy; hepatitis virus; exosomal mirnas ... See more keywords
Ischaemic colitis during pegylated interferon-alpha monotherapy for chronic hepatitis B: A case report
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DOI: 10.1097/md.0000000000033378
Abstract: Rationale: Pegylated interferon-alpha (PEG-IFN-α) is available for the treatment of hepatitis B virus infection, which is better than interferon-alpha (IFN-α) for the inhibition of hepatitis B virus replication. Ischemic colitis has been described from non-pegylated… read more here.
Keywords: colitis; interferon alpha; hepatitis; ischemic colitis ... See more keywords
Comparable HIV suppression by pegylated-IFN-α2a or pegylated-IFN-α2b during a 4-week analytical treatment interruption.
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DOI: 10.1097/qad.0000000000002961
Abstract: We report on the post-hoc analysis of three clinical studies (NCT01935089, NCT00594880, and NCT00051818) with chronically HIV-infected, immune-reconstituted individuals with similar entry criteria, and demographics interrupting antiretroviral therapy (ART) without or with 5 weeks of weekly… read more here.
Keywords: interruption; pegylated ifn; comparable hiv; week ... See more keywords
The UK SPIRIT 1 trial in newly-diagnosed chronic myeloid leukaemia (CML)
Sign Up to like & getrecommendations! Published in 2022 at "British journal of haematology"
DOI: 10.1111/bjh.17961
Abstract: Although the UK National Cancer Research Institute’s SPIRIT 1 trial closed in 2009 due to poor recruitment, we thought it would be useful to the haematology community to report the outcome. This study closed early… read more here.
Keywords: spirit; newly diagnosed; trial; peg ifn ... See more keywords
Higher efficacy of pegylated interferon‐α2b add‐on therapy in hepatitis B envelope antigen‐positive chronic hepatitis B patients on tenofovir monotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology Research"
DOI: 10.1111/hepr.13049
Abstract: Monotherapy with pegylated interferon‐α (Peg‐IFNα) or the nucleos(t)ide analogs (NA) currently approved for treating chronic hepatitis B (CHB) has limited efficacy. Studies on the combination of Peg‐IFNα/NA have shown conflicting results. We investigated whether sequentially… read more here.
Keywords: chronic hepatitis; hepatitis; pegylated interferon; efficacy ... See more keywords