Analysis of PEG-lipid anchor length on lipid nanoparticle pharmacokinetics and activity in a mouse model of traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01846b
Abstract: Traumatic brain injury (TBI) affects millions of people worldwide, yet there are currently no therapeutics that address the long-term impairments that develop in a large portion of survivors. Lipid nanoparticles (LNPs) are a promising therapeutic… read more here.
Keywords: peg lipid; traumatic brain; pharmacokinetics activity; brain ... See more keywords
A PEG-lipid-free COVID-19 mRNA vaccine triggers robust immune responses in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Materials horizons"
DOI: 10.1039/d2mh01260j
Abstract: COVID-19 mRNA vaccines represent a completely new category of vaccines and play a crucial role in controlling the COVID-19 pandemic. In this study, we have developed a PEG-lipid-free two-component mRNA vaccine (PFTCmvac) by formulating mRNA… read more here.
Keywords: lipid free; responses mice; peg lipid; covid mrna ... See more keywords