Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2399
Abstract: Flavonoid compounds play an effective role in cancer suppression and today nanocarriers play an important role in improving the physicochemical properties and transmission of these compounds. In this study, polyethylene glycol‐modified albumin nanoparticles were synthesized… read more here.
Keywords: peg nps; cancer cells; folic acid; polyethylene glycol ... See more keywords
Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.10.028
Abstract: &NA; The overexpression of CD44 in cancer cells reroutes number of oncogenic pathways including the central Pi3K/Akt/NF‐kB pathway leading to cancer progression and malignancy. Herein, we developed hyaluronic acid‐modified poly(DL‐lactic‐co‐glycolic acid)‐poly (ethylene glycol) nanoparticles (PLGA‐PEG‐HA… read more here.
Keywords: plga peg; peg nps; hyaluronic acid; cancer cells ... See more keywords
Development of Octreotide-Loaded Chitosan and Heparin Nanoparticles: Evaluation of Surface Modification Effect on Physicochemical Properties and Macrophage Uptake.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.05.002
Abstract: Octreotide (OCT) is a therapeutic peptide which is administered for the treatment of acromegaly. The purpose of this study was to design a new polyethylene glycol (PEG)-conjugated nanoparticle (PEG-NP) to overcome the short half-life and… read more here.
Keywords: heparin; macrophage uptake; peg nps; nps peg ... See more keywords
Hypoxia Inhibitor Combined with Chemotherapeutic Agents for Antitumor and Antimetastatic Efficacy against Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00068
Abstract: Chemotherapy is the main treatment method for osteosarcoma in the clinic. However, drug resistance and its poor antimetastatic effects greatly limit its clinical application. In this work, dual-drug nanoparticles (NPs) containing albendazole (ABZ) and doxorubicin… read more here.
Keywords: peg nps; osteosarcoma; antitumor antimetastatic; antimetastatic efficacy ... See more keywords
Dopamine Receptor-Mediated Binding and Cellular Uptake of Polydopamine-Coated Nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "ACS nano"
DOI: 10.1021/acsnano.1c06081
Abstract: Polydopamine (PDA)-coated nanoparticles (NPs) are emerging carriers of therapeutic agents for nanomedicine applications due to their biocompatibility and abundant entry to various cell types, yet it remains unknown whether their cellular entry engages cell-surface receptors.… read more here.
Keywords: pda; peg nps; d2dr; cellular uptake ... See more keywords
Promoting intracellular delivery of sub-25 nm nanoparticles via defined levels of compression.
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale"
DOI: 10.1039/c8nr04927k
Abstract: Many investigations into the interactions between nanoparticles and mammalian cells entail the use of culture systems that do not account for the effect of extracellular mechanical cues, such as compression. In this work, we present… read more here.
Keywords: compression; defined levels; compressive stress; delivery ... See more keywords
Cholesterol–PEG comodified poly (N-butyl) cyanoacrylate nanoparticles for brain delivery: in vitro and in vivo evaluations
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2016.1233590
Abstract: Abstract This study investigated cholesterol–polyethylene glycol (PEG) comodified poly (ethyleneglycol)-poly (lactide) nanoparticles (CLS-PEG NPs) as a novel, biodegradable brain drug delivery system and included an evaluation of its in vitro and in vivo properties. To… read more here.
Keywords: delivery; peg nps; brain; cls peg ... See more keywords
Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-020-00680-9
Abstract: Background Developing a universal strategy to improve the specificity and sensitivity of PEGylated nanoaparticles (PEG-NPs) for assisting in the diagnosis of tumors is important in multimodality imaging. Here, we developed the anti-methoxypolyethylene glycol (mPEG) bispecific… read more here.
Keywords: mpeg; mpeg her2; multimodality imaging; peg nps ... See more keywords
An In Vivo Investigation of Ascorbic Acid Tethered Polymeric Nanoparticles for Effectual Brain Transport of Rivastigmine.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220516093425
Abstract: INTRODUCTION The goal of this study was to see if ascorbic acid grafted polylactic glycolic acid-b-polyethylene glycol nanoparticles (PLGA-b-PEG NPs) might boost the carrying or transport capacity of rivastigmine (RSM) to the brain via choroid… read more here.
Keywords: peg nps; ascorbic acid; brain; acid ... See more keywords
Polydopamine encapsulated new indocyanine green theranostic nanoparticles for enhanced photothermal therapy in cervical cancer HeLa cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.984166
Abstract: Photothermal therapy (PTT) has attracted extensive attention in cancer treatment due to its non-invasiveness, high efficiency, and repeatability in recent years. Photothermal agents (PTAs) are the key factor for PTT. Recently, although an increasing number… read more here.
Keywords: peg nps; ir820 pda; pda peg;
PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020407
Abstract: This study aims to design a pH-responsive dual-loaded nanosystem based on PEGylated chitosan nanoparticles loaded with ascorbic acid (AA) and oxaliplatin (OX) for the effective treatment of breast cancer. In this regard, non-PEGylated and PEGylated… read more here.
Keywords: pegylated chitosan; peg nps; nps nps; nps peg ... See more keywords