Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice.
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DOI: 10.1016/j.xphs.2022.01.023
Abstract: Bioconjugation with polyethylene glycol (PEG) is important for protein drug development as it has improved biological stability. In contrast, proteins including PEGylated ones are susceptible to physicochemical stresses. Particularly, protein drugs in solution may form… read more here.
Keywords: peg ova; dropping stress; subvisible particles; antibody production ... See more keywords