Facile fabrication of dasatinib laden multifunctional polymeric micelles: Evaluation of anti‐proliferative and apoptotic activities in human cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.56376
Abstract: Dasatinib (DAS) has recently gained significant interest for its anticancer potential. Yet, the lipophilicity inherent in DAS limited its potential use as a chemotherapeutic drug. This study aimed to examine the effectiveness of polyethylene glycol‐polycaprolactone… read more here.
Keywords: anti proliferative; cancer; cancer cells; peg pcl ... See more keywords
Effect of incorporating Elaeagnus angustifolia extract in PCL-PEG-PCL nanofibers for bone tissue engineering
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers of Chemical Science and Engineering"
DOI: 10.1007/s11705-018-1742-7
Abstract: Plants have been used for medicinal purposes for thousands of years but they are still finding new uses in modern times. For example, Elaeagnus angustifolia (EA) is a medicinal herb with antinociceptive, anti-inflammatory, antibacterial and… read more here.
Keywords: engineering; peg pcl; pcl nanofibers; pcl peg ... See more keywords
Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(&egr;‐caprolactone) diblock copolymers: Beyond a paradigm
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.09.048
Abstract: ABSTRACT Polymeric nanoparticles (NPs) of poly(&egr;‐caprolactone) (PCL) covered with a hydrophilic poly(ethylene glycol) (PEG) shell are usually prepared from diblock PEG‐PCL copolymers through different techniques. Furthermore PEG, NPs can be decorated with targeting ligands to… read more here.
Keywords: peg pcl; folate; surface; peg ... See more keywords
Pyramid-Shaped PEG-PCL-PEG Polymeric-Based Model Systems for Site-Specific Drug Delivery of Vancomycin with Enhance Antibacterial Efficacy
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b04064
Abstract: Antibacterial resistance remains a major global problem due to frequent prescriptions, leading to significant toxicities. To overcome the limitations of antibiotic therapy, it is highly desirable to provide site-specific delivery of drugs with controlled release.… read more here.
Keywords: peg pcl; pcl peg; delivery; drug ... See more keywords
Diffusive probe penetration for characterization of diffusion-governing length scales in amphiphilic PEG-PCL co-networks.
Sign Up to like & getrecommendations! Published in 2025 at "Soft matter"
DOI: 10.1039/d5sm00629e
Abstract: We investigate the penetrative probe diffusion in a model amphiphilic polymer co-network (APCN) synthesized via a hetero-complementary coupling reaction between 2-(4-nitrophenyl)-benzoxazinone-terminated tetra-poly(ε-caprolactone) (t-PCL) and amino-terminated tetra-poly(ethylene glycol) (t-PEG) using isorefractive dynamic light scattering (DLS). We… read more here.
Keywords: length; diffusion governing; governing length; peg pcl ... See more keywords
In vivo evaluation of cisplatin-loaded PEG-PCL block copolymeric nanoparticles for anticancer drug delivery
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz244.069
Abstract: Abstract Background Cisplatin has proved itself an effective therapeutic approach in a variety of solid tumors. However, its therapeutic concentration was limited since the presence of variant inevitable side effects. Nanoparticles (NPs) developed from amphiphilic… read more here.
Keywords: peg pcl; loaded peg; cisplatin; drug ... See more keywords
Enhanced antiproliferative activity of antibody-functionalized polymeric nanoparticles for targeted delivery of anti-miR-21 to HER2 positive gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18066
Abstract: MiR-21 is an oncogenic miR frequently elevated in gastric cancer. Overexpression of miR-21 decreases the sensitivity of gastric cancer cells to trastuzumab, which is a humanized monoclonal antibody targeting human epidermal growth factor receptor 2.… read more here.
Keywords: peg pcl; gastric cancer; mir; delivery ... See more keywords
Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone
Sign Up to like & getrecommendations! Published in 2018 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2017.26590.6513
Abstract: Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to… read more here.
Keywords: peg pcl; pcl peg; delivery; pcl ... See more keywords
In situ preparation of hetero-polymers/clay nanocomposites by CUAAC click chemistry
Sign Up to like & getrecommendations! Published in 2021 at "Turkish Journal of Chemistry"
DOI: 10.3906/kim-2007-62
Abstract: A series of polymer/clay nanocomposites containing mechanistically two different polymers, poly(ethylene glycol) (PEG) and poly(epsilon caprolactone) (PCL), were prepared by simultaneous copper(I)-catalyzed alkyne-azide cycloaddition click reactions. Both clickable polymers, PEG-Alkyne and PCL-Alkyne, were simultaneously clicked… read more here.
Keywords: chemistry situ; peg pcl; mmt; chemistry ... See more keywords