Skin permeability and transdermal delivery route of 30-nm cyclosporin A-loaded nanoparticles using PLGA-PEG-PLGA triblock copolymer
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.124866
Abstract: Abstract The aim of this study was to investigate the skin permeability of a hydrophobic drug when using poly( dl -lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly( dl -lactide-co-glycolide) triblock copolymers (PLGA-PEG-PLGA) as a drug carrier. Two types of PLGA-PEG-PLGA… read more here.
Keywords: plga nanoparticles; drug; plga peg; peg plga ... See more keywords
Degradation of thermoresponsive laponite/PEG-b-PLGA nanocomposite hydrogels controlled by blending PEG-b-PLGA diblock copolymers with different PLGA molecular weights
Sign Up to like & getrecommendations! Published in 2021 at "Polymer Degradation and Stability"
DOI: 10.1016/j.polymdegradstab.2021.109535
Abstract: Abstract The thermoresponsive gelation behavior and the degradation behavior of the nanocomposites consisting of poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PEG-b-PLGA) diblock copolymers and clay nanoparticles (laponite) (laponite/PEG-b-PLGA nanocomposites) were studied by changing the blend ratio of… read more here.
Keywords: peg plga; plga diblock; plga; diblock copolymers ... See more keywords
Structure-Performance Relationships of Temperature-Responsive PLGA-PEG-PLGA Gels for Sustained Release of Bone Morphogenetic Protein-2.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.07.007
Abstract: PLGA (poly(lactic-co-glycolic) acid)-PEG (polyethylene glycol)-PLGA synthesis conditions have an impact on the physicochemical features of the copolymer and its usefulness as biomaterial. This study reports on an analysis of the composition and structural properties of… read more here.
Keywords: protein; plga peg; peg plga; plga ... See more keywords
DPD simulations on morphologies and structures of blank PLGA-b-PEG-b-PLGA polymeric micelles and docetaxel-loaded PLGA-b-PEG-b-PLGA polymeric micelles
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00940d
Abstract: Dissipative particle dynamics (DPD) simulation was used to study the morphologies and structures of blank (no drug) poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) (PLGA-b-PEG-b-PLGA) polymeric micelles and the docetaxel (Dtx)-loaded PLGA-b-PEG-b-PLGA polymeric micelles. We focused on the… read more here.
Keywords: plga polymeric; peg plga; plga; polymeric micelles ... See more keywords
DOTAP-Incorporated PEG-PLGA Nanoparticles for Efficient In Vitro and In Vivo Gene Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2018.2470
Abstract: The application of nucleic acids as therapeutic agents has been obstructed by the lack of efficient and safe systems for the delivery of the therapeutic DNA into target cells. Nanoparticle (NP) vectors based on biocompatible… read more here.
Keywords: delivery; gene delivery; vivo gene; peg plga ... See more keywords
Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-018-0356-z
Abstract: BackgroundMemantine, drug approved for moderate to severe Alzheimer’s disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to increase drug’s action on… read more here.
Keywords: drug; alzheimer disease; peg plga; mem peg ... See more keywords
Evaluation of Anti-Tumor Efficacy of Vorinostat Encapsulated Self-Assembled Polymeric Micelles in Solid Tumors
Sign Up to like & getrecommendations! Published in 2018 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-018-1149-2
Abstract: Vorinostat (VOR), a potent HDAC inhibitor, suffers from low solubility and poor absorption, which hinders its successful application in therapy, especially in the treatment of solid tumors. In this study, an effort to improve the… read more here.
Keywords: solid tumors; vor; plga micelles; peg plga ... See more keywords
Preparation and characterization of PLGA-based magnetic polymer nanoparticles for targeting pancreatic adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666230324091555
Abstract: AIMS This study aims to develop a novel tumor-targeted molecular probe for pancreatic cancer imaging. The objective of this is to prepare a CKAAKN peptide-conjugated poly (lactic-co-glycolic acid)-poly (ethylene glycol) amphiphilic polymer (CKAAKN-PEG-PLGA) for the… read more here.
Keywords: pancreatic cancer; peg plga; plga; ckaakn peg ... See more keywords
Drug-loaded PEG-PLGA nanoparticles for cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.990505
Abstract: Nanoparticles based on single-component synthetic polymers, such as poly (lactic acid-co-glycolic acid) (PLGA), have been extensively studied for antitumor drug delivery and adjuvant therapy due to their ability to encapsulate and release drugs, as well… read more here.
Keywords: nanoparticles cancer; peg plga; plga; plga nanoparticles ... See more keywords
Caffeic Acid Phenethyl Ester Loaded PEG–PLGA Nanoparticles Enhance Wound Healing in Diabetic Rats
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox12010060
Abstract: Delayed wound healing is a serious complication of diabetes and a main reason for foot amputation. Caffeic acid phenethyl ester (CAPE) is a main active constituent of honeybee propolis with reported appealing pharmacological activities. In… read more here.
Keywords: wound healing; loaded peg; peg plga; cape ... See more keywords
PEG-b-PLGA Nanoparticles Loaded with Geraniin from Phyllanthus Watsonii Extract as a Phytochemical Delivery Model
Sign Up to like & getrecommendations! Published in 2020 at "Applied Sciences"
DOI: 10.3390/app10144891
Abstract: The study outlined a standardized double emulsion method for simple poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG-b-PLGA) nanoparticle (NP) synthesis. The PEG-b-PLGA NP was also used for entrapment of geraniin as a simple model system for phytochemical delivery.… read more here.
Keywords: phytochemical delivery; model; peg plga; plga ... See more keywords