Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2042999
Abstract: ABSTRACT To investigate the mechanism of paternally expressed gene (PEG10) in regulating neuroblastoma (NB) progression. PEG10 expression was detected using quantitative real-time reverse transcription polymerase-chain reaction (qRT-PCR). The interaction of miR-449a and PEG10 or ribosomal… read more here.
Keywords: mir 449a; proliferation migration; peg10; invasion ... See more keywords
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abg6155
Abstract: Hitching a ride with a retroelement Retroviruses and retroelements have inserted their genetic code into mammalian genomes throughout evolution. Although many of these integrated virus-like sequences pose a threat to genomic integrity, some have been… read more here.
Keywords: peg10; virus like; protein peg10; delivery ... See more keywords
PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression
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DOI: 10.1186/s12935-018-0610-3
Abstract: Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene… read more here.
Keywords: tumor progression; peg10; regulatory mechanisms; expression ... See more keywords
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
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DOI: 10.1371/journal.pone.0214110
Abstract: Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long terminal repeat) retrotransposon and retains Gag and Pol-like domains. Here… read more here.
Keywords: placental; peg10; gag protein; trophoblast stem ... See more keywords
Knockdown of long non-coding RNA PEG10 inhibits growth, migration and invasion of gastric carcinoma cells via up-regulating miR-3200.
Sign Up to like & getrecommendations! Published in 2018 at "Neoplasma"
DOI: 10.4149/neo_2018_171204n794
Abstract: Gastric cancer is the main leading cause of cancer-related death worldwide. The aberrant expression of paternally expressed gene 10 (PEG10) is involved in development of a range of cancers. However, the potential biological function and… read more here.
Keywords: gastric carcinoma; peg10; regulating mir; mir 3200 ... See more keywords