Pegaspargase in Practice: Minimizing Toxicity, Maximizing Benefit
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DOI: 10.1007/s11899-021-00638-0
Abstract: The incorporation of pegaspargase in chemotherapy regimens has significantly improved the prognosis of ALL in adults. However, pegaspargase use poses many challenges due to its unique toxicity profile. Here, we review pegaspargase’s most clinically significant… read more here.
Keywords: benefit; minimizing toxicity; pegaspargase practice; toxicity ... See more keywords
Pegaspargase: A Review in Acute Lymphoblastic Leukaemia
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DOI: 10.1007/s40265-019-01120-1
Abstract: Pegaspargase (Oncaspar®), a pegylated form of native Escherichia coli-derived l-asparaginase (hereafter referred as E. colil-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent… read more here.
Keywords: colil asparaginase; treatment; pegaspargase; paediatric adult ... See more keywords
Combination of Anti-PD-1 Antibody, Anlotinib and Pegaspargase “Sandwich” With Radiotherapy in Localized Natural Killer/T Cell Lymphoma
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DOI: 10.3389/fimmu.2022.766200
Abstract: Asparaginase/pegaspargase containing regimens combined with radiotherapy are highly effective and considered the cornerstone of localized Natural killer/T-cell lymphoma (NKTL) treatment. However, these chemotherapy regimens inevitably cause relatively high incidence of treatment-related adverse events (TRAEs). Herein… read more here.
Keywords: localized natural; anlotinib pegaspargase; natural killer; pegaspargase ... See more keywords