Efficacy of pegvorhyaluronidase alfa (PEGPH20) plus FOLFIRINOX in a preclinical model of human pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e16244
Abstract: e16244Background: Hyaluronan (HA) accumulates in the solid tumor microenvironment, and is associated with poor drug penetration and negative clinical outcomes. Pegvorhyaluronidase alfa (P) is a nov... read more here.
Keywords: pegvorhyaluronidase alfa; folfirinox preclinical; efficacy pegvorhyaluronidase; plus folfirinox ... See more keywords
Plasma hyaluronan is a predictive marker for pegvorhyaluronidase alfa (PEGPH20; PVHA) response in a phase II study of pancreatic ductal adenocarcinoma (PDAC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.4_suppl.404
Abstract: 404 Background: Hyaluronan (HA) can be a constituent of the tumor microenvironment (TME). Accumulation of HA in the TME may result in elevated interstitial pressure, vascular compression, hypoxia, and reduced drug delivery and immune cell… read more here.
Keywords: pegph20 pvha; alfa pegph20; pegvorhyaluronidase alfa; pvha ... See more keywords