Reversed-Phase HPLC: A fast and efficient analytical method to quantify docetaxel-loaded pegylated liposomes in release study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100382
Abstract: Docetaxel is an anticancer that belongs to the family of taxanes and acts in the inhibition of cell proliferation through the polymerization of microtubules. The aim of this study was the development and validation a… read more here.
Keywords: hplc; analytical method; reversed phase; pegylated liposomes ... See more keywords
Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.11.070
Abstract: Liposomal delivery is a well-established approach to increase the therapeutic index of drugs, mainly in the field of cancer chemotherapy. Here, we report the preparation and characterization of a new liposomal formulation of a derivative… read more here.
Keywords: liposomes incorporating; pegylated liposomes; preparation pegylated; lipophilic lomeguatrib ... See more keywords
Development of High-Functionality and -Quality Lipids with RGD Peptide Ligands: Application for PEGylated Liposomes and Analysis of Intratumoral Distribution in a Murine Colon Cancer Model.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00476
Abstract: High-functionality and -quality (HFQ) lipids have a discrete molecular weight and good water dispersibility and can be produced by solid-phase peptide synthesis. Therefore, HFQ lipids are a promising material for the preparation of ligand-grafted PEGylated… read more here.
Keywords: grafted pegylated; pegylated liposomes; colon; intratumoral distribution ... See more keywords
Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c03946
Abstract: PEGylated nanocarriers have gained increasing attention due to reduced toxicity and enhanced circulation compared with free drugs. According to guidances of drug regulatory departments worldwide, it is crucial to determine free and liposomal drug concentrations;… read more here.
Keywords: separation; anti peg; peg scfv; pegylated liposomes ... See more keywords
PEGylated Liposomes Accumulate in the Areas Relevant to Skin Toxicities via Passive Extravasation across "Leaky" Endothelium.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c00423
Abstract: PEGylated liposome is the cornerstone platform for modern drug delivery. Unfortunately, as exemplified by PEGylated liposomal doxorubicin (aka Doxil), altered doxorubicin pharmacokinetics causes off-target accumulation in the skin, including the palms and feet, leading to… read more here.
Keywords: microscopy; skin toxicities; areas relevant; extravasation ... See more keywords
Aggregation of polyethylene glycol polymers suppresses receptor-mediated endocytosis of PEGylated liposomes.
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale"
DOI: 10.1039/c7nr09011k
Abstract: The PEGylated liposome, composed of an aqueous core and a fluid state lipid bilayer shell, is one of the few Food and Drug Administration (FDA) approved drug delivery platforms. To prevent the absorption of serum… read more here.
Keywords: pegylated liposomes; peg polymers; endocytosis; polyethylene glycol ... See more keywords
Preparation and in vivo safety evaluations of antileukemic homoharringtonine-loaded PEGylated liposomes
Sign Up to like & getrecommendations! Published in 2017 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2016.1275670
Abstract: Abstract In order to improve the in vivo safety and specific delivery efficiency of the antileukemic homoharringtonine (HHT) at the targets, the long-circulating PEGylated liposomes loaded with HHT (LCLipo-HHT) were prepared. Their physical characteristics, in… read more here.
Keywords: vivo safety; hht; pegylated liposomes; antileukemic homoharringtonine ... See more keywords
Octreotide-Targeted Lcn2 siRNA PEGylated Liposomes as a Treatment for Metastatic Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineering"
DOI: 10.3390/bioengineering8040044
Abstract: Lcn2 overexpression in metastatic breast cancer (MBC) can lead to cancer progression by inducing the epithelial-to-mesenchymal transition and enhancing tumor angiogenesis. In this study, we engineered a PEGylated liposomal system encapsulating lipocalin 2 (Lcn2) small… read more here.
Keywords: pegylated liposomes; lcn2 sirna; breast cancer; metastatic breast ... See more keywords
The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314974
Abstract: Nanoparticles (NPs) are commonly modified with tumor-targeting moieties that recognize proteins overexpressed on the extracellular membrane to increase their specific interaction with target cells. Nanobodies (Nbs), the variable domain of heavy chain-only antibodies, are a… read more here.
Keywords: density; nbs per; per liposome; pegylated liposomes ... See more keywords
PEGylated Liposomes Loaded with Carbamate Inhibitor ANP0903 Trigger Apoptosis by Enhancing ER Stress in HepG2 Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054552
Abstract: Liver cancer is one of the most common causes of cancer death worldwide. In recent years, substantial progress has been made in the development of systemic therapies, but there is still the need for new… read more here.
Keywords: anp0903; cancer; inhibitor; carbamate ... See more keywords
Hyaluronated and PEGylated Liposomes as a Potential Drug-Delivery Strategy to Specifically Target Liver Cancer and Inflammatory Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031062
Abstract: Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and is characterized by poor clinical outcomes, with the majority of patients not being eligible for curative therapy and treatments only being applicable for early-stage… read more here.
Keywords: liver cancer; hcc; strategy; drug delivery ... See more keywords