Catalytic Activation of Esterases by PEGylation for Polyester Synthesis
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201900451
Abstract: In this work we explored PEGylation as an efficient strategy to improve esterase's catalytic performance. For this, we PEGylated three esterases, namely lipase from Candida antarctica B (CALB), lipase from Thermomyces lanuginosus (TL) and cutinase… read more here.
Keywords: calb; cutinase; lipase; activity ... See more keywords
Utilizing functionalized bromomaleimides for fluorogenic conjugation and PEGylation of enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Polymer International"
DOI: 10.1002/pi.5740
Abstract: Two efficient enzyme conjugation techniques have been explored by exploiting the reactions of bromomaleimides. The conjugations utilize monobromoand dibromomaleimides, which have been reacted with reduced disulfide bonds or terminal amines in α-chymotrypsin and human lysozyme.… read more here.
Keywords: conjugation; functionalized bromomaleimides; utilizing functionalized; pegylation ... See more keywords
Facilitated water-selective permeation via PEGylation of graphene oxide membrane
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Membrane Science"
DOI: 10.1016/j.memsci.2018.09.026
Abstract: Abstract Manipulating the chemical structure of GO interlayer channels is an efficient strategy to improve the selective molecular transport through the resultant GO membrane. In this work, PEGylation of GO membrane was performed to incorporate… read more here.
Keywords: water; permeation; graphene; facilitated water ... See more keywords
Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Natural Science: Materials International"
DOI: 10.1016/j.pnsc.2019.10.002
Abstract: Abstract A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin (DOX) was used as a model drug to evaluate… read more here.
Keywords: microscopy; mesoporous silica; silica nanoparticles; hollow mesoporous ... See more keywords
Improving particle quality in cryo-EM analysis using a PEGylation method.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.05.004
Abstract: Cryo-electron microscopy (cryo-EM) is widely used for structural biology studies and has been developed extensively in recent years. However, its sample vitrification process is a major limitation because it causes severe particle aggregation and/or denaturation.… read more here.
Keywords: analysis; method; improving particle; cryo ... See more keywords
In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.10.025
Abstract: Single-walled carbon nanotubes (SWCNTs) attract great interest in biomedical fields including application for drug delivery system. In this study, we developed a novel gene delivery system employing SWCNTs associated with polycationic and amphiphilic H-(-Lys-Trp-Lys-Gly-)7-OH [(KWKG)7]… read more here.
Keywords: delivery; kwkg; single walled; gene delivery ... See more keywords
Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00059
Abstract: Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinase (MMP) family of proteins, whose members are key regulators of the proteolysis of extracellular matrix components and hence of multiple biological processes. In… read more here.
Keywords: timp2; mmp; pegylation; chemistry ... See more keywords
PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00276
Abstract: Here, we explore whether PEGylation of antibodies can modulate their biodistribution to the eye, an organ once thought to be immune privileged but has recently been shown to be accessible to IV-administered large molecules, such… read more here.
Keywords: mertk; biodistribution; pegylation; mertk antibody ... See more keywords
Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00281
Abstract: The development of chemical strategies for site-specific protein modification now enables researchers to attach polyethylene glycol (PEG) to a protein drug at one or more specific locations (i.e., protein PEGylation). However, aside from avoiding enzyme… read more here.
Keywords: proteolytic stability; polyethylene glycol; conjugation strategy; stability ... See more keywords
Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00383
Abstract: Mitochondrial oxidative damage is related to diverse pathologies, including cancer and neurodegenerative diseases. Shielding mitochondria from oxidative damage with mitochondriotropic antioxidants is by now considered an effective therapeutic strategy. Despite the success of the approach,… read more here.
Keywords: mitochondriotropic; mitochondriotropic antioxidant; strategy; antioxidant based ... See more keywords
Noncovalent PEGylation via Sulfonatocalix[4]arene-A Crystallographic Proof.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00769
Abstract: Noncovalent or supramolecular PEGylation, in combination with the site of administration, has great potential to increase the half-life of therapeutic proteins. To date, a variety of noncovalent PEGylation strategies have been devised. However, questions remain… read more here.
Keywords: noncovalent pegylation; pegylation via; pegylation; sulfonatocalix arene ... See more keywords