Silencing of gasdermin D by siRNA-loaded PEI-Chol lipopolymers potently relieves acute gouty arthritis through inhibiting pyroptosis.
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DOI: 10.1021/acs.molpharmaceut.0c00229
Abstract: Gasdermin D (GSDMD) serves as a causal role in NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis eruption, which has been regarded as a potential therapeutic target for pyroptosis-related diseases including acute gouty arthritis. In the… read more here.
Keywords: gouty arthritis; pei chol; pyroptosis; acute gouty ... See more keywords