Pellino3 ligase negatively regulates Influenza B dependent RIG-I signaling through downregulation of TRAF3 mediated induction of the transcription factor IRF3 and IFNβ production.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13637
Abstract: Viral infection activates the innate immune system, which recognizes viral components by a variety of pattern recognition receptors and initiates signaling cascades leading to the production of pro-inflammatory cytokines. To date, signaling cascades triggered after… read more here.
Keywords: pellino3; production; pellino3 ligase; ifn production ... See more keywords