Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.02.014
Abstract: Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study,… read more here.
Keywords: pyroptosis; targeting mir; pelp1; metformin induces ... See more keywords
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
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DOI: 10.1126/sciadv.adw4603
Abstract: The rixosome is a large multisubunit complex that initiates RNA decay during critical nuclear transactions including ribosome assembly and heterochromatin maintenance. The overall architecture of the complex remains undefined because several subunits contain intrinsically disordered… read more here.
Keywords: pelp1 coordinates; modular assembly; coordinates modular; rixosome ... See more keywords
Abstract 4315: PELP1 oncogene targeted therapy for the treatment of ovarian cancer
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DOI: 10.1158/1538-7445.am2025-4315
Abstract: Ovarian cancer (OCa) is the most lethal of all gynecologic malignancies in the United States. Despite the initial responses observed in OCa patients to standard combinations of surgical and cytotoxic chemotherapy, roughly 80% of these… read more here.
Keywords: cancer; treatment; therapy; oca ... See more keywords
Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC
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DOI: 10.3390/cancers14040930
Abstract: Simple Summary The proto-oncogene PELP1 is commonly overexpressed in many cancers including triple negative breast cancer (TNBC). In this study, we utilized global proteomic and RNA-seq approaches to elucidate the molecular mechanisms by which PELP1… read more here.
Keywords: ribosomal proteins; expression; pelp1; tnbc ... See more keywords