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   Articles with "pembrolizumab chemotherapy" as a keyword



Abstract PS5-02: The incidence and risk of cardiovascular events associated with pembrolizumab in patients with breast cancer

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recommendations! Published in 2025 at "Clinical Cancer Research"

DOI: 10.1158/1557-3265.sabcs24-ps5-02

Abstract: Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, ICIs have been linked to serious immune-related cardiovascular adverse events. Pembrolizumab has recently been approved for breast cancer treatment, but data on its impact on… read more here.

Keywords: pembrolizumab chemotherapy; cancer; breast cancer; risk ... See more keywords

Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study

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recommendations! Published in 2025 at "Journal of Clinical Oncology"

DOI: 10.1200/jco-25-00748

Abstract: PURPOSE The phase III randomized open-label LEAP-015 study (ClinicalTrials.gov identifier: NCT04662710) evaluated first-line lenvatinib plus pembrolizumab and chemotherapy versus chemotherapy for advanced metastatic gastroesophageal adenocarcinoma. METHODS Eligible participants 18 years and older with untreated human… read more here.

Keywords: pembrolizumab chemotherapy; lenvatinib plus; chemotherapy; plus pembrolizumab ... See more keywords
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First-line pembrolizumab plus chemotherapy versus chemotherapy in patients with advanced esophageal cancer: Chinese subgroup analysis of KEYNOTE-590.

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recommendations! Published in 2021 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2021.39.15_suppl.4049

Abstract: 4049 Background: In the randomized, double-blind, placebo-controlled, multicenter, phase 3 KEYNOTE-590 study (NCT03189719), pembrolizumab + chemotherapy provided superior OS, PFS, and ORR versus chemotherapy with a manageable safety profile in patients with untreated locally advanced/unresectable… read more here.

Keywords: chemotherapy; versus; pembrolizumab chemotherapy; chemotherapy arm ... See more keywords