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Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02815-1
Abstract: Advancements in medicine have enabled the use of monoclonal antibodies in the field of oncology. However, the new adverse effects of immunotherapeutic agents are still being reported. We present the first case of pembrolizumab-induced fatal…
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Keywords:
colitis concurrent;
concurrent giardia;
fatal colitis;
colitis ... See more keywords
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Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.12.019
Abstract: Regulatory approval for the anti-programmed death 1 (PD-1) receptor monoclonal antibody (mAb) pembrolizumab represented a major therapeutic advance for patients with metastatic solid cancers [1]. As anticipated, immune checkpoint blockade of the PD-1/programmed death-ligand 1…
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Keywords:
polymyositis patient;
fatal polymyositis;
patient pembrolizumab;
pembrolizumab induced ... See more keywords
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Published in 2022 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1934-1940
Abstract: A 55-year-old man was treated with combined immunochemotherapy (pembrolizumab, carboplatin and pemetrexed) because of non-small cell lung cancer (NSCLC). In addition, the patient had a medical history of chronic hepatitis B/D virus infection and cystic…
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Keywords:
pembrolizumab induced;
exacerbation hepatitis;
hepatitis;
treatment ... See more keywords
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Published in 2018 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000661
Abstract: Immune checkpoint inhibitors have revolutionized cancer therapy. Given their mechanism of action, immune-related adverse events have been associated with their use. We present the first documented case of pembrolizumab-induced grade IV neutropenia. A 73-year-old women…
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Keywords:
case;
grade neutropenia;
pembrolizumab induced;
pembrolizumab ... See more keywords
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Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14663
Abstract: Pembrolizumab is an immune checkpoint inhibitor designed to block the interaction between programmed cell death‐1 and programmed cell death‐ligands 1 and 2. It shows efficacy in the treatment of patients with advanced nonsmall‐cell lung cancer,…
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Keywords:
vitiligo patient;
induced vitiligo;
pembrolizumab induced;
pembrolizumab ... See more keywords
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Published in 2020 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15366
Abstract: Pembrolizumab-induced reactivation of bullous pemphigoid Dear Editor, Pembrolizumab is a programmed cell death protein 1 (PD1) inhibitor approved for use in several solid carcinomas. It reverses T-cell suppression, causing immune stimulation. Consequently, various immune-related adverse…
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Keywords:
dermatology;
induced reactivation;
bullous pemphigoid;
reactivation ... See more keywords
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Published in 2018 at "BMJ Case Reports"
DOI: 10.1136/bcr-2017-223252
Abstract: Pembrolizumab is an immune checkpoint inhibitor that significantly improves clinical outcomes in numerous solid organ malignancies. Despite successful therapeutic responses, this new drug comes with a constellation of adverse reactions. Herein, we chronicle the case…
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Keywords:
toxicities pembrolizumab;
new toxicities;
induced myocarditis;
pembrolizumab induced ... See more keywords
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Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2019-232505
Abstract: Increasing numbers of patients are now offered immunotherapy as part of their cancer treatment. These treatments, while often very effective, have a wide range of adverse effects that are distinct from those of traditional chemotherapy…
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Keywords:
haemolytic anaemia;
cholangitis;
autoimmune haemolytic;
pembrolizumab induced ... See more keywords
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Published in 2018 at "Radiology"
DOI: 10.1148/radiol.2018180572
Abstract: Pembrolizumab is a programmed cell death protein 1, or PD-1, inhibitor therapy immunotherapy for patients with advanced melanoma. This report discusses a series of documented cases of sarcoid-like reactions associated with this therapy. Three patients…
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Keywords:
melanoma;
like reactions;
metastatic disease;
pembrolizumab induced ... See more keywords
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Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e21577
Abstract: e21577Background: Anti-PD-1 checkpoint immunotherapies have distinct toxicity profiles that include immune-related adverse events (irAE). Objective response rates (ORR) appear to be higher in patie...
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Keywords:
immune related;
events survival;
induced immune;
related adverse ... See more keywords
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Published in 2020 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v8.i18.4100
Abstract: BACKGROUND Pembrolizumab is an anti-programmed death receptor 1 (PD-1) that was shown to have a tolerable safety profile with 17% of grade 3-4 drug-related adverse events, notable response rate of 16% with median duration of…
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Keywords:
mucositis;
response;
case;
report ... See more keywords