Pembrolizumab-induced immune-mediated fatal colitis with concurrent giardia infection
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02815-1
Abstract: Advancements in medicine have enabled the use of monoclonal antibodies in the field of oncology. However, the new adverse effects of immunotherapeutic agents are still being reported. We present the first case of pembrolizumab-induced fatal… read more here.
Keywords: colitis concurrent; concurrent giardia; fatal colitis; colitis ... See more keywords
A patient with pembrolizumab-induced fatal polymyositis.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.12.019
Abstract: Regulatory approval for the anti-programmed death 1 (PD-1) receptor monoclonal antibody (mAb) pembrolizumab represented a major therapeutic advance for patients with metastatic solid cancers [1]. As anticipated, immune checkpoint blockade of the PD-1/programmed death-ligand 1… read more here.
Keywords: polymyositis patient; fatal polymyositis; patient pembrolizumab; pembrolizumab induced ... See more keywords
Pembrolizumab-induced acute exacerbation of hepatitis D.
Sign Up to like & getrecommendations! Published in 2022 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1934-1940
Abstract: A 55-year-old man was treated with combined immunochemotherapy (pembrolizumab, carboplatin and pemetrexed) because of non-small cell lung cancer (NSCLC). In addition, the patient had a medical history of chronic hepatitis B/D virus infection and cystic… read more here.
Keywords: pembrolizumab induced; exacerbation hepatitis; hepatitis; treatment ... See more keywords
A case of severe Pembrolizumab-induced neutropenia.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000661
Abstract: Immune checkpoint inhibitors have revolutionized cancer therapy. Given their mechanism of action, immune-related adverse events have been associated with their use. We present the first documented case of pembrolizumab-induced grade IV neutropenia. A 73-year-old women… read more here.
Keywords: case; grade neutropenia; pembrolizumab induced; pembrolizumab ... See more keywords
Pembrolizumab‐induced vitiligo in a patient with lung adenocarcinoma: A case report
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14663
Abstract: Pembrolizumab is an immune checkpoint inhibitor designed to block the interaction between programmed cell death‐1 and programmed cell death‐ligands 1 and 2. It shows efficacy in the treatment of patients with advanced nonsmall‐cell lung cancer,… read more here.
Keywords: vitiligo patient; induced vitiligo; pembrolizumab induced; pembrolizumab ... See more keywords
Pembrolizumab‐induced reactivation of bullous pemphigoid
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15366
Abstract: Pembrolizumab-induced reactivation of bullous pemphigoid Dear Editor, Pembrolizumab is a programmed cell death protein 1 (PD1) inhibitor approved for use in several solid carcinomas. It reverses T-cell suppression, causing immune stimulation. Consequently, various immune-related adverse… read more here.
Keywords: dermatology; induced reactivation; bullous pemphigoid; reactivation ... See more keywords
New drugs and new toxicities: pembrolizumab-induced myocarditis
Sign Up to like & getrecommendations! Published in 2018 at "BMJ Case Reports"
DOI: 10.1136/bcr-2017-223252
Abstract: Pembrolizumab is an immune checkpoint inhibitor that significantly improves clinical outcomes in numerous solid organ malignancies. Despite successful therapeutic responses, this new drug comes with a constellation of adverse reactions. Herein, we chronicle the case… read more here.
Keywords: toxicities pembrolizumab; new toxicities; induced myocarditis; pembrolizumab induced ... See more keywords
Pembrolizumab-induced autoimmune haemolytic anaemia and cholangitis
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2019-232505
Abstract: Increasing numbers of patients are now offered immunotherapy as part of their cancer treatment. These treatments, while often very effective, have a wide range of adverse effects that are distinct from those of traditional chemotherapy… read more here.
Keywords: haemolytic anaemia; cholangitis; autoimmune haemolytic; pembrolizumab induced ... See more keywords
Pembrolizumab-induced Sarcoid-like Reactions during Treatment of Metastatic Melanoma.
Sign Up to like & getrecommendations! Published in 2018 at "Radiology"
DOI: 10.1148/radiol.2018180572
Abstract: Pembrolizumab is a programmed cell death protein 1, or PD-1, inhibitor therapy immunotherapy for patients with advanced melanoma. This report discusses a series of documented cases of sarcoid-like reactions associated with this therapy. Three patients… read more here.
Keywords: melanoma; like reactions; metastatic disease; pembrolizumab induced ... See more keywords
Pembrolizumab-induced immune related adverse events and survival outcomes in advanced melanoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e21577
Abstract: e21577Background: Anti-PD-1 checkpoint immunotherapies have distinct toxicity profiles that include immune-related adverse events (irAE). Objective response rates (ORR) appear to be higher in patie... read more here.
Keywords: immune related; events survival; induced immune; related adverse ... See more keywords
Management of pembrolizumab-induced steroid refractory mucositis with infliximab: A case report
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v8.i18.4100
Abstract: BACKGROUND Pembrolizumab is an anti-programmed death receptor 1 (PD-1) that was shown to have a tolerable safety profile with 17% of grade 3-4 drug-related adverse events, notable response rate of 16% with median duration of… read more here.
Keywords: mucositis; response; case; report ... See more keywords