Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Medicine"
DOI: 10.1038/s41591-020-0918-0
Abstract: An increasing fraction of patients with metastatic cancer develop leptomeningeal dissemination of disease (LMD), and survival is dismal1–3. We conducted a single-arm, phase 2 study of pembrolizumab in patients with solid tumor malignancies and LMD… read more here.
Keywords: phase; pembrolizumab patients; patients leptomeningeal; single arm ... See more keywords
Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers
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DOI: 10.1136/jitc-2021-002473
Abstract: Background The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown. Methods We undertook a phase II trial of pembrolizumab in patients with LMM from solid tumors. Eligible patients had… read more here.
Keywords: cns response; pembrolizumab patients; solid tumors; patients leptomeningeal ... See more keywords
Abstract CT206: A phase I study of binimetinib, a MEK inhibitor, in combination with pembrolizumab in patients with advanced non-small cell lung cancer (NSCLC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct206
Abstract: Introduction: MEK inhibition combined with PD-1 axis inhibition may achieve a greater clinical response than either inhibitor alone due to increased T-cell infiltration of tumours. We combined binimetinib with pembrolizumab in patients with stage IV… read more here.
Keywords: cell; pembrolizumab patients; combination; response ... See more keywords
Safety and efficacy of tisagenlecleucel plus pembrolizumab in patients with r/r DLBCL: phase 1b PORTIA study results
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DOI: 10.1182/bloodadvances.2022007779
Abstract: Key Points • The best response rates were observed with pembrolizumab before tisagenlecleucel; however, definitive conclusions cannot be made.• Pembrolizumab did not augment the cellular expansion of tisagenlecleucel but delayed peak expansion in the day… read more here.
Keywords: tisagenlecleucel plus; pembrolizumab patients; plus pembrolizumab; safety efficacy ... See more keywords
Phase II trial of pembrolizumab in patients (pts) with incurable platinum refractory germ cell tumors (GCT).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.4520
Abstract: 4520Background: Despite remarkable results with salvage standard-dose (SDCT) or high-dose chemotherapy (HDCT), about 15% of pts with relapsed GCT are incurable. Immune therapy with Pembrolizumab is a novel approach for salvage in pts with metastatic… read more here.
Keywords: pembrolizumab patients; gct; trial pembrolizumab; phase trial ... See more keywords
Afatinib in combination with pembrolizumab in patients (pts) with stage IIIB/IV squamous cell carcinoma (SCC) of the lung.
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DOI: 10.1200/jco.2018.36.15_suppl.tps9117
Abstract: TPS9117Background: Afatinib and pembrolizumab have demonstrated improvements in the outcomes of pts with SCC of the lung and are approved as monotherapy. Afatinib is a selective and irreversible Er... read more here.
Keywords: combination pembrolizumab; pembrolizumab patients; patients pts; afatinib combination ... See more keywords
Impact of Histological Variants on Clinical Responses to Pembrolizumab in Patients With Metastatic Urothelial Cancer
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DOI: 10.21873/anticanres.15851
Abstract: Background: The efficacy of anti-programmed celldeath protein 1 treatment in patients with urothelial carcinoma (UC) with molecular subtypes of histological variants has not been investigated. This study aimed to examine the impact of histological variants… read more here.
Keywords: pembrolizumab patients; histological variants; impact histological; patients metastatic ... See more keywords