Efficacy and Safety of Pembrolizumab Plus Docetaxel vs Docetaxel Alone in Patients With Previously Treated Advanced Non-Small Cell Lung Cancer: The PROLUNG Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2020.0409
Abstract: Importance Because of socioeconomic factors, many patients with advanced non-small cell lung cancer (NSCLC) do not receive immunotherapy in the first-line setting. It is unknown if the combination of immunotherapy with chemotherapy can provide clinical… read more here.
Keywords: pembrolizumab plus; advanced non; safety; plus docetaxel ... See more keywords
Pembrolizumab plus chemotherapy in Japanese patients with triple‐negative breast cancer: Results from KEYNOTE‐355
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DOI: 10.1002/cam4.5757
Abstract: Pembrolizumab plus chemotherapy improved progression‐free survival (PFS) and overall survival (OS) compared with placebo plus chemotherapy in patients with previously untreated locally recurrent inoperable or metastatic triple‐negative breast cancer with tumor programmed cell death ligand… read more here.
Keywords: plus chemotherapy; pembrolizumab plus; triple negative; negative breast ... See more keywords
Cost-effectiveness Analysis of Pembrolizumab Plus Axitinib Versus Sunitinib in First-line Advanced Renal Cell Carcinoma in China
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DOI: 10.1007/s40261-019-00820-6
Abstract: Background and ObjectivesIn first-line treatment of advanced renal cell carcinoma (aRCC), the KEYNOTE-426 study demonstrated a significant progression-free survival and overall survival for pembrolizumab plus axitinib in comparison with sunitinib. The objective of the current… read more here.
Keywords: pembrolizumab plus; cost; versus sunitinib; plus axitinib ... See more keywords
Results from the randomized KEYNOTE-355 study of pembrolizumab plus chemotherapy for Asian patients with advanced TNBC
Sign Up to like & getrecommendations! Published in 2024 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-024-00679-7
Abstract: In the phase 3 KEYNOTE-355 study (NCT02819518), pembrolizumab plus chemotherapy demonstrated statistically significant and clinically meaningful improvements in progression-free survival (PFS) and overall survival (OS) versus placebo plus chemotherapy among patients with previously untreated locally… read more here.
Keywords: plus chemotherapy; pembrolizumab plus; placebo; keynote 355 ... See more keywords
Cost effectiveness of pembrolizumab plus lenvatinib compared with chemotherapy for treating previously treated advanced endometrial cancer in Sweden
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DOI: 10.1080/13696998.2024.2329022
Abstract: Abstract Objective Pembrolizumab plus lenvatinib was recently approved for the treatment of advanced or recurrent endometrial carcinoma in women with disease progression on or following prior treatment with a platinum‑containing therapy in any setting, and… read more here.
Keywords: compared chemotherapy; pembrolizumab plus; plus lenvatinib; cost ... See more keywords
Pembrolizumab plus axitinib for the treatment of advanced renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2021.1903321
Abstract: ABSTRACT Introduction: The dominant paradigm of sequential therapy of metastatic renal cell carcinoma (mRCC) with single agents has recently been challenged by improved outcomes obtained with combined regimens with immune checkpoint inhibitors. These combined regimens… read more here.
Keywords: renal cell; pembrolizumab plus; cell carcinoma; plus axitinib ... See more keywords
5-year real-world outcomes with first-line pembrolizumab plus chemotherapy in advanced/metastatic NSCLC.
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DOI: 10.1080/1750743x.2025.2569856
Abstract: BACKGROUND First-line pembrolizumab plus chemotherapy has demonstrated durable, clinically meaningful survival benefits over 5 years, compared with chemotherapy alone, in pivotal clinical trials for patients with metastatic NSCLC. This retrospective study aimed to evaluate 5-year real-world… read more here.
Keywords: line pembrolizumab; year; pembrolizumab plus; first line ... See more keywords
Pembrolizumab or pembrolizumab plus chemotherapy versus standard of care chemotherapy in patients with advanced gastric or gastroesophageal junction adenocarcinoma: Asian subgroup analysis of KEYNOTE-062
Sign Up to like & getrecommendations! Published in 2022 at "Japanese Journal of Clinical Oncology"
DOI: 10.1093/jjco/hyac188
Abstract: Abstract Objective First-line pembrolizumab with/without chemotherapy versus chemotherapy was evaluated in programmed death ligand 1 combined positive score ≥1, locally advanced/unresectable or metastatic gastric cancer/gastrooesophageal junction cancer in the KEYNOTE-062 study. We present results for… read more here.
Keywords: plus chemotherapy; pembrolizumab plus; chemotherapy versus; pembrolizumab ... See more keywords
Immune checkpoint inhibitors for first-line treatment of advanced non-small-cell lung cancer: A systematic review and network meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Thoracic cancer"
DOI: 10.1111/1759-7714.14148
Abstract: OBJECTIVE Currently, several immune checkpoint inhibitors (ICIs) treatment for advanced non-small-cell lung cancer (NSCLC) have been investigated; their overall efficacy and safety remain unclear. METHODS We searched electronic databases such as PubMed, EMBASE, and the… read more here.
Keywords: chemotherapy; platinum based; pembrolizumab plus; plus platinum ... See more keywords
Pembrolizumab plus chemotherapy in Japanese patients with persistent, recurrent or metastatic cervical cancer: Results from KEYNOTE‐826
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DOI: 10.1111/cas.15479
Abstract: Pembrolizumab plus chemotherapy with or without bevacizumab demonstrated prolonged progression‐free survival (PFS) and overall survival (OS) versus chemotherapy in patients with persistent, recurrent, or metastatic cervical cancer in the phase 3, randomized, double‐blind, placebo‐controlled KEYNOTE‐826… read more here.
Keywords: plus chemotherapy; patients persistent; pembrolizumab plus; placebo ... See more keywords
Pembrolizumab plus lenvatinib for all advanced endometrial cancer? Maybe not
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2022-003419
Abstract: It was with great enthusiasm that I read the recently published KEYNOTE 775. Pembrolizumab plus lenvatinib showed unprecedented results for advanced, recurrent, or metastatic endometrial cancer with improvements in overall survival, progressionfree survival, response rates,… read more here.
Keywords: endometrial cancer; plus lenvatinib; pembrolizumab plus; response ... See more keywords