Chemo-Selective Cys-Pen Disulfide for Proximity-Induced Cysteine Cross-Linking.
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DOI: 10.1021/acschembio.2c00083
Abstract: Disulfide-rich architectures are valuable pharmacological tools or therapeutics. Besides, a ligand-induced conjugate strategy offers potential advantages in potency, selectivity, and duration of action for novel covalent drugs. Combining the plentiful disulfide-rich architecture library and ligand-induced… read more here.
Keywords: ligand induced; disulfide; pen disulfide; cys pen ... See more keywords