Mapping pathogenic mutations suggests an innovative structural model for the pendrin (SLC26A4) transmembrane domain.
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DOI: 10.1016/j.biochi.2016.10.002
Abstract: Human pendrin (SLC26A4) is an anion transporter mostly expressed in the inner ear, thyroid and kidney. SLC26A4 gene mutations are associated with a broad phenotypic spectrum, including Pendred Syndrome and non-syndromic hearing loss with enlarged… read more here.
Keywords: transmembrane; transmembrane domain; model; pendrin slc26a4 ... See more keywords
Acute genetic ablation of pendrin lowers blood pressure in mice
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DOI: 10.1093/ndt/gfw393
Abstract: Background Pendrin, the chloride/bicarbonate exchanger of β-intercalated cells of the renal connecting tubule and the collecting duct, plays a key role in NaCl reabsorption by the distal nephron. Therefore, pendrin may be important for the… read more here.
Keywords: pendrin; ablation pendrin; blood pressure; acute genetic ... See more keywords
SLC26A4 Mutation Promotes Cell Apoptosis by Inducing Pendrin Transfer, Reducing Cl− Transport, and Inhibiting PI3K/Akt/mTOR Pathway
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DOI: 10.1155/2022/6496799
Abstract: Objective Pendrin is encoded by SLC26A4, which is expressed in the apical membrane of inner ear epithelial cells and drives chloride reabsorption in the apical septum. In the inner ear, pendrin dysfunction and hypofunctional mutations… read more here.
Keywords: slc26a4; pi3k akt; pendrin; akt mtor ... See more keywords
Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020
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DOI: 10.1161/hypertensionaha.121.16492
Abstract: Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distribution of… read more here.
Keywords: pendrin positive; pendrin; aldosterone; intercalated cells ... See more keywords
Most bicarbonate secretion by Calu‐3 cells is mediated by CFTR and independent of pendrin
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DOI: 10.14814/phy2.13641
Abstract: Bicarbonate plays an important role in airway host defense, however, its transport mechanisms remain uncertain. Here we examined the relative contributions of the anion channel CFTR (cystic fibrosis transmembrane conductance regulator, ABCC7) and the anion… read more here.
Keywords: calu cells; secretion calu; calu; hco3 ... See more keywords