Regulation of VDAC1 contributes to the cardioprotective effects of penehyclidine hydrochloride during myocardial ischemia/reperfusion
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DOI: 10.1016/j.yexcr.2018.04.004
Abstract: ABSTRACT Penehyclidine hydrochloride (PHC) preconditioning can alleviate myocardial ischemia/reperfusion (I/R) injury and inhibits the upregulation of voltage‐dependent anion channel 1 (VDAC1) during I/R. To validate that VDAC1 is a bona fide target of PHC for… read more here.
Keywords: overexpression; penehyclidine hydrochloride; cardioprotective effects; myocardial ischemia ... See more keywords
Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride
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DOI: 10.2147/dddt.s177435
Abstract: Background Penehyclidine hydrochloride (PHC) is an anticholinergic drug manufactured in China. It is used widely in clinics as a reversal agent in cases of organic phosphorus poisoning and as a preanesthetic medication. Compared with other… read more here.
Keywords: penehyclidine hydrochloride; organic phosphorus; poisoning preanesthetic; pharmacological properties ... See more keywords
Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride
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DOI: 10.2147/dddt.s224282
Abstract: Background/Aims To investigate the postconditioning protective effect of penehyclidine hydrochloride (PHC) against anoxia/reoxygenation (A/R) injury in H9c2 cells along with the involved mechanism and timing effect. Methods We divided H9c2 cells into 7 groups: control… read more here.
Keywords: phc; anoxia reoxygenation; injury; penehyclidine hydrochloride ... See more keywords
[Anti-inflammatory effects of penehyclidine hydrochloride on acute respiratory distress syndrome in rats].
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DOI: 10.3760/cma.j.issn.2095-4352.2018.08.010
Abstract: OBJECTIVE To investigate the anti-inflammatory effect of penehyclidine hydrochloride on oleic acid-induced acute respiratory distress syndrome (ARDS) in rats. METHODS According to randomize number table method, 30 adult male Sprague-Dawley (SD) rats were divided into… read more here.
Keywords: anti inflammatory; penehyclidine hydrochloride; group; lung tissue ... See more keywords