Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior.
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DOI: 10.1021/acs.jmedchem.0c01498
Abstract: The G protein-coupled receptor 52 (GPR52) is an orphan receptor that is selectively expressed in the striatum and regulates various brain functions through activation of cAMP-dependent pathways. GPR52 has been identified as a promising therapeutic… read more here.
Keywords: gpr52 agonist; brain penetrant; discovery potent; penetrant gpr52 ... See more keywords