Structural Bases for the Involvement of Phosphatidylinositol-4,5-bisphosphate in the Internalization of the Cell-Penetrating Peptide Penetratin.
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DOI: 10.1021/acschembio.1c00974
Abstract: Cell-penetrating peptides cross cell membranes through various parallel internalization pathways. Herein, we analyze the role of the negatively charged lipid phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) in the internalization of Penetratin. Contributions of both inner leaflet and outer leaflet… read more here.
Keywords: cell; internalization; cell penetrating; phosphatidylinositol bisphosphate ... See more keywords
Systematic Screening of Penetratin’s Protein Targets by Yeast Proteome Microarrays
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DOI: 10.3390/ijms23020712
Abstract: Cell-penetrating peptides (CPPs) have distinct properties to translocate across cell envelope. The key property of CPPs to translocation with attached molecules has been utilized as vehicles for the delivery of several potential drug candidates that… read more here.
Keywords: proteome microarrays; targets penetratin; protein targets; process ... See more keywords