Design and synthesis of benzodiazepines as brain penetrating PARP-1 inhibitors
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DOI: 10.1080/14756366.2022.2053524
Abstract: Abstract The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors cannot cross the blood-brain barrier, thus limiting their application in the central nervous system. Here, 55… read more here.
Keywords: brain; inhibition; brain penetrating; penetrating parp ... See more keywords