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Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700444
Abstract: Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP),…
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Keywords:
conjugate;
penetrating peptide;
cell penetrating;
activation ... See more keywords
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Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0321-y
Abstract: AbstractIn the present work, DNA nanopore was composed of a bundle of six DNA duplexes folded from six DNA strands and functionalized with Ramos cell aptamer and cell-penetrating peptide (CPP). Herein, we present a unique…
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Keywords:
dna;
penetrating peptide;
aptamer cell;
cell penetrating ... See more keywords
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Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.05.030
Abstract: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer, and one therapeutic approach is to target both the AMPK and autophagy pathways in order to synergistically promote programmed cell death. Here, a…
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Keywords:
hcc;
lipid modified;
modified cell;
penetrating peptide ... See more keywords
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Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113447
Abstract: Substrate-based sirtuin inhibitors target bacterial genome and RNA and provide a promising approach to address bacterial resistance issues, if cellular internalisation can be achieved. We designed N-trifluoroacetyl lysine and N-thioacetyl lysine peptides (KP 13, KP…
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Keywords:
thioacetyl lysine;
lysine;
penetrating peptide;
study ... See more keywords
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1
Published in 2022 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2022.03.010
Abstract: With the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also…
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Keywords:
peptide applications;
cell penetrating;
unleashing cell;
penetrating peptide ... See more keywords
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0
Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00465
Abstract: Mitochondria are essential targets for treatment of diseases with mitochondrial disorders such as diabetes, cancer, cardiovascular and neurodegenerative disease. Mitochondria penetrating peptides (MPPs) are composed of cationic and hydrophobic amino acids that can target and…
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Keywords:
argine phenylalanine;
long term;
penetrating peptide;
mitochondria penetrating ... See more keywords
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Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c00929
Abstract: There is significant potential in exploiting antibody specificity to develop new therapeutic treatments. However, intracellular protein delivery is a paramount challenge because of the difficulty in transporting large, polar molecules across cell membranes. Cell-penetrating peptide…
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Keywords:
peptide mimics;
penetrating peptide;
cell penetrating;
cppm protein ... See more keywords
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Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00924
Abstract: Cyclic cell-penetrating peptide 12 (CPP12) is highly efficient for the cytosolic delivery of a variety of cargo molecules into mammalian cells in vitro and in vivo. However, its cytosolic entry efficiency is substantially reduced at…
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Keywords:
cell penetrating;
cytosolic delivery;
penetrating peptide;
cyclic cell ... See more keywords
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Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b13354
Abstract: Cancer immunotherapy can enhance the antitumor effect of drugs through a combinatorial approach in a synergistic manner. However, the effective targeted delivery of various drugs remains a challenge. We generated a peptide assembling tumor-targeted nano…
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Keywords:
penetrating peptide;
peptide assembling;
breast cancer;
cancer ... See more keywords
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Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25448-z
Abstract: Protein delivery with cell-penetrating peptide is opening up the possibility of using targets inside cells for therapeutic or biological applications; however, cell-penetrating peptide-mediated protein delivery commonly suffers from ineffective endosomal escape and low tolerance in…
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Keywords:
protein delivery;
peptide;
delivery;
multifunctional chimaeric ... See more keywords
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Published in 2021 at "Nature Chemistry"
DOI: 10.1038/s41557-021-00661-x
Abstract: Enabling the cellular delivery and cytosolic bioavailability of functional proteins constitutes a major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich peptide additives can enhance the cellular uptake of protein–CPP conjugates in…
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Keywords:
peptide additives;
penetrating peptide;
cell penetrating;
cell surface ... See more keywords