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   Articles with "penetrating peptide" as a keyword



A Conjugate of an Anti‐Epidermal Growth Factor Receptor (EGFR) VHH and a Cell‐Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700444

Abstract: Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP),… read more here.

Keywords: conjugate; penetrating peptide; cell penetrating; activation ... See more keywords

Efficient Synthesis of Cleavable Cell‐Penetrating Peptide–Cargo Conjugate via Low‐Equivalent of Cell‐Penetrating Peptide Activated by 2,2′‐Dithiodipyridine

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recommendations! Published in 2025 at "ChemBioChem"

DOI: 10.1002/cbic.202500032

Abstract: Cell‐penetrating peptides (CPPs) are favored for protein delivery due to their efficiency, rapidity, and low toxicity. However, conjugation of CPPs to proteins often requires significant amounts of CPPs to ensure yields, which also may result… read more here.

Keywords: cargo; synthesis cleavable; penetrating peptide; cell ... See more keywords

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500242

Abstract: Folic acid is an essential component of many metabolic processes, including the synthesis of nucleoproteins, purines, and pyrimidines, and is a recommended supplement to lower the incidence of various disorders. Folic acid and folate‐loaded nanoparticles… read more here.

Keywords: folic acid; penetrating peptide; cellular uptake; acid ... See more keywords

DNA nanopore functionalized with aptamer and cell-penetrating peptide for tumor cell recognition

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recommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-017-0321-y

Abstract: AbstractIn the present work, DNA nanopore was composed of a bundle of six DNA duplexes folded from six DNA strands and functionalized with Ramos cell aptamer and cell-penetrating peptide (CPP). Herein, we present a unique… read more here.

Keywords: dna; penetrating peptide; aptamer cell; cell penetrating ... See more keywords

Lipid-modified cell-penetrating peptide-based self-assembly micelles for co-delivery of narciclasine and siULK1 in hepatocellular carcinoma therapy.

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recommendations! Published in 2018 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2018.05.030

Abstract: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer, and one therapeutic approach is to target both the AMPK and autophagy pathways in order to synergistically promote programmed cell death. Here, a… read more here.

Keywords: hcc; lipid modified; modified cell; penetrating peptide ... See more keywords

Synthesis and antibacterial study of cell-penetrating peptide conjugated trifluoroacetyl and thioacetyl lysine modified peptides.

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recommendations! Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113447

Abstract: Substrate-based sirtuin inhibitors target bacterial genome and RNA and provide a promising approach to address bacterial resistance issues, if cellular internalisation can be achieved. We designed N-trifluoroacetyl lysine and N-thioacetyl lysine peptides (KP 13, KP… read more here.

Keywords: thioacetyl lysine; lysine; penetrating peptide; study ... See more keywords

Unleashing cell-penetrating peptide applications for immunotherapy.

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recommendations! Published in 2022 at "Trends in molecular medicine"

DOI: 10.1016/j.molmed.2022.03.010

Abstract: With the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also… read more here.

Keywords: peptide applications; cell penetrating; unleashing cell; penetrating peptide ... See more keywords

Mitochondria penetrating peptide conjugated TAMRA for live-cell long-term tracking.

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recommendations! Published in 2019 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.9b00465

Abstract: Mitochondria are essential targets for treatment of diseases with mitochondrial disorders such as diabetes, cancer, cardiovascular and neurodegenerative disease. Mitochondria penetrating peptides (MPPs) are composed of cationic and hydrophobic amino acids that can target and… read more here.

Keywords: argine phenylalanine; long term; penetrating peptide; mitochondria penetrating ... See more keywords

Protein Binding and Release by Polymeric Cell-Penetrating Peptide Mimics.

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recommendations! Published in 2021 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.1c00929

Abstract: There is significant potential in exploiting antibody specificity to develop new therapeutic treatments. However, intracellular protein delivery is a paramount challenge because of the difficulty in transporting large, polar molecules across cell membranes. Cell-penetrating peptide… read more here.

Keywords: peptide mimics; penetrating peptide; cell penetrating; cppm protein ... See more keywords

Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.

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recommendations! Published in 2022 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.1c00924

Abstract: Cyclic cell-penetrating peptide 12 (CPP12) is highly efficient for the cytosolic delivery of a variety of cargo molecules into mammalian cells in vitro and in vivo. However, its cytosolic entry efficiency is substantially reduced at… read more here.

Keywords: cell penetrating; cytosolic delivery; penetrating peptide; cyclic cell ... See more keywords

Dual-blockade immune checkpoint for breast cancer treatment based on a tumor-penetrating peptide assembling nanoparticle.

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recommendations! Published in 2019 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.9b13354

Abstract: Cancer immunotherapy can enhance the antitumor effect of drugs through a combinatorial approach in a synergistic manner. However, the effective targeted delivery of various drugs remains a challenge. We generated a peptide assembling tumor-targeted nano… read more here.

Keywords: penetrating peptide; peptide assembling; breast cancer; cancer ... See more keywords