Preparation and cellular uptake of bicyclic‐peptide cargo clicked to cell penetrating peptides
Sign Up to like & getrecommendations! Published in 2018 at "Peptide Science"
DOI: 10.1002/pep2.24037
Abstract: Cell penetrating peptides (CPPs) are frequently used to deliver peptide cargo into cells where they can exert their biological activity. Their success, however, can be dependent on the cargo, the cell type, and other variables… read more here.
Keywords: peptide; penetrating peptides; cell penetrating; peptide cargo ... See more keywords
Nα‐Methylation of arginine: Implications for cell‐penetrating peptides
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3468
Abstract: The field of cell‐penetrating peptides is dominated by the use of oligomers of arginine residues. Octanol–water partitioning in the presence of an anionic lipid is a validated proxy for cell‐penetrative efficacy. Here, we add one,… read more here.
Keywords: penetrating peptides; arginine implications; methylation arginine; cell penetrating ... See more keywords
Cell-Penetrating Peptides Delivering siRNAs: An Overview.
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DOI: 10.1007/978-1-0716-1298-9_18
Abstract: Cell-Penetrating Peptides (CPP) are valuable tools capable of crossing the plasma membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are double-stranded RNA molecules capable of silencing the expression of a specific protein… read more here.
Keywords: peptides delivering; penetrating peptides; cell penetrating; overview ... See more keywords
Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery.
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DOI: 10.1007/978-1-0716-1752-6_24
Abstract: This chapter describes the use of cell-penetrating peptides (CPPs) as carriers for transepithelial delivery of therapeutic peptides. Assessment of transepithelial peptide permeation and the mechanisms of action that permeability enhancing drug carriers exert on the… read more here.
Keywords: penetrating peptides; delivery; drug; cell penetrating ... See more keywords
Isolation of Primary Hepatocytes for Testing Tumor Penetrating Peptides.
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DOI: 10.1007/978-1-0716-1752-6_26
Abstract: Methods for isolation of human primary cells is an important tool to be able to test the effect of several drugs for the treatment of diseases. Protocols have been described for the isolation of healthy… read more here.
Keywords: primary hepatocytes; penetrating peptides; tumor penetrating; isolation primary ... See more keywords
Artificial Evolutionary Optimization Process to Improve the Functionality of Cell Penetrating Peptides.
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DOI: 10.1007/978-1-0716-1752-6_3
Abstract: Crossing cellular membranes is a versatile molecular property that allows for a wide variety of peptides with cell penetrating capabilities. This broadness complicates identification of candidates suited best for a specific application. To facilitate the… read more here.
Keywords: penetrating peptides; artificial evolutionary; optimization process; cell penetrating ... See more keywords
In Silico Design of Chemically Modified Cell-Penetrating Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1752-6_4
Abstract: In the past few decades, a large number of cell-penetrating peptides (CPPs) have been discovered. These CPPs have a wide range of applications including drug delivery vehicles. Numerous in silico tools have been developed over… read more here.
Keywords: penetrating peptides; silico design; cell penetrating; design chemically ... See more keywords
Synthetic Molecular Evolution of Cell Penetrating Peptides.
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DOI: 10.1007/978-1-0716-1752-6_5
Abstract: Rational design and optimization of cell penetrating peptides (CPPs) is difficult to accomplish because of the lack of quantitative sequence-structure-function rules describing the activity and because of the complex, poorly understood mechanisms of CPPs. Synthetic… read more here.
Keywords: cell penetrating; synthetic molecular; molecular evolution; penetrating peptides ... See more keywords
Self-assembly of Filamentous Cell Penetrating Peptides for Gene Delivery.
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DOI: 10.1007/978-1-4939-7811-3_17
Abstract: Cell penetrating peptides (CPPs) have been proven to be an effective vector to deliver a variety of membrane-impermeable macromolecules, such as DNAs, siRNAs, and proteins. Conventional single-chain CPPs typically suffer from severe protease degradation and… read more here.
Keywords: self assembly; penetrating peptides; delivery; cell penetrating ... See more keywords
Antimicrobial and Cell-Penetrating Peptides: How to Understand Two Distinct Functions Despite Similar Physicochemical Properties.
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DOI: 10.1007/978-981-13-3588-4_7
Abstract: Antimicrobial and cell-penetrating peptides are both classes of membrane-active peptides sharing similar physicochemical properties. Both kinds of peptides have attracted much attention owing to their specific features. AMPs disrupt cell membranes of bacteria and display… read more here.
Keywords: similar physicochemical; penetrating peptides; physicochemical properties; cell penetrating ... See more keywords
TargetCPP: accurate prediction of cell-penetrating peptides from optimized multi-scale features using gradient boost decision tree
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-020-00307-z
Abstract: Cell-penetrating peptides (CPPs) are short length permeable proteins have emerged as drugs delivery tool of therapeutic agents including genetic materials and macromolecules into cells. Recently, CPP has become a hotspot avenue for life science research… read more here.
Keywords: penetrating peptides; targetcpp; cell penetrating; cpps ... See more keywords