Sidechain Engineering in Cell-Penetrating Poly(disulfide)s
Sign Up to like & getrecommendations! Published in 2017 at "Helvetica Chimica Acta"
DOI: 10.1002/hlca.201600370
Abstract: Cell-penetrating poly(disulfide)s (CPDs) have been introduced recently to explore new ways to enter into cells. In this report, we disclose a general method to covalently modify the sidechains of CPDs. Compatibility of copper-catalyzed alkyne-azide cycloaddition… read more here.
Keywords: disulfide; penetrating poly; cell penetrating; poly disulfide ... See more keywords
In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06840g
Abstract: Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its "always" positive charge. Herein, we developed pH-responsive CPDIMD that… read more here.
Keywords: cell penetrating; delivery; penetrating poly; poly disulfide ... See more keywords
Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07020g
Abstract: Monitoring gene delivery has significant benefits in gene therapy. Herein, we report a nanoquencher system by doping a FRET pair during nucleic acid-assisted cell penetrating poly(disulfide) (CPD) formation. Our results show that this strategy not… read more here.
Keywords: cell penetrating; penetrating poly; gene delivery; gene ... See more keywords