Stabilizing Effects of Bacterial Biofilms: EPS Penetration and Redistribution of Bed Stability Down the Sediment Profile
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Geophysical Research"
DOI: 10.1002/2017jg004050
Abstract: Biofilms, consisting of microorganisms and their secreted extracellular polymeric substances (EPS), serve as “ecosystem engineers” stabilizing sedimentary environments. Natural sediment bed provides an excellent substratum for biofilm growth. The porous structure and rich nutrients allow… read more here.
Keywords: bacterial biofilms; penetration; stabilizing effects; sediment ... See more keywords
Piezo‐STING Agonists Enhance Tumor Penetration and Catalytic‐immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202419032
Abstract: The cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway is an important innate immune pathway that has shown remarkable potential in cancer immunotherapy. However, the clinical therapeutic efficacy is limited due… read more here.
Keywords: piezo sting; immunotherapy; sting agonists; tumor ... See more keywords
Charge‐Guided Cartilage‐Penetrating Micro/Nanocarriers That Inhibit Piezo1 and Protect Cartilage to Alleviate Osteoarthritis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202422280
Abstract: Osteoarthritis (OA), characterized by progressive cartilage degeneration and chronic joint pain, represents a major global health challenge. While intra‐articular drug delivery is a common therapeutic approach, its efficacy is limited by poor drug penetration through… read more here.
Keywords: micro nanocarriers; cartilage; penetration; charge guided ... See more keywords
Dual‐Driven Janus Nanomotors Combined with a Size‐Shrinkage Strategy for Enhanced Tumor Penetration and Synergistic Chemo/Photothermal/Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202510089
Abstract: Further applications of nanotherapeutic systems are greatly hindered by their unsatisfactory tumor permeability. Therefore, achieving an optimal balance between long circulation time and deep penetration is imperative. Janus nanomotors have garnered significant attention owing to… read more here.
Keywords: tumor penetration; tumor; enhanced tumor; penetration ... See more keywords
A Fibrinogen‐Mimicking, Activated‐Platelet‐Sensitive Nanocoacervate Enhances Thrombus Targeting and Penetration of Tissue Plasminogen Activator for Effective Thrombolytic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201265
Abstract: The development of a fibrinolytic system with long circulation time, high thrombus targeting, efficient thrombus penetration, effective thrombolysis, and minimal hemorrhagic risk remains a major challenge. Herein, inspired by fibrinogen binding to activated platelets in… read more here.
Keywords: rgd chi; penetration; tpa; chi tpa ... See more keywords
Natural MOF‐Like Photocatalytic Nanozymes Alleviate Tumor Pressure for Enhanced Nanodrug Penetration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400596
Abstract: In oncological nanomedicine, overcoming the dual‐phase high interstitial pressure in the tumor microenvironment is pivotal for enhancing the penetration and efficacy of nanotherapeutics. The elevated tumor interstitial solid pressure (TISP) is largely attributed to the… read more here.
Keywords: pressure; like photocatalytic; mof like; tumor ... See more keywords
Microglial Membrane-Coated Biomimetic Nanoplatform for Enhanced Blood-Brain Barrier Penetration and Targeted Photodynamic Therapy in Orthotopic Glioblastoma.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502808
Abstract: Glioblastoma multiforme (GBM) continues to pose a significant challenge in the field of neuro‐oncology primarily because of the limited penetration of therapeutics across the blood‐brain barrier (BBB) and the presence of immunosuppressive tumor microenvironments. To… read more here.
Keywords: biomimetic nanoplatform; blood brain; tumor; brain barrier ... See more keywords
Effective Penetration of the Oxidized Keratin-Rebonding Materials Into Hair Shafts Based on Charge Conversion.
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DOI: 10.1002/adhm.202503538
Abstract: Materials bearing multiple positive charges reinforce damaged hair fibers through ionic interactions with negatively charged sulfonate groups present in oxidized keratin. However, their strong surface binding often hinders deep penetration into the hair shaft. To… read more here.
Keywords: penetration; damaged hair; charge conversion; hair ... See more keywords
Virion-Like Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201707240
Abstract: Poor drug penetration into tumor cells and tissues is a worldwide difficulty in cancer therapy. A strategy is developed for virion-like membrane-breaking nanoparticles (MBNs) to smoothly accomplish tumor-activated cell-and-tissue dual-penetration for surmounting impermeable drug-resistant cancer.… read more here.
Keywords: penetration; membrane breaking; virion like; tissue ... See more keywords
A Size-Changeable Collagenase-Modified Nanoscavenger for Increasing Penetration and Retention of Nanomedicine in Deep Tumor Tissue.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.201906745
Abstract: The complex tumor microenvironment constitutes a variety of barriers to prevent nanoparticles (NPs) delivery and results in extremely low accumulation of nanomedicines in solid tumors. Here, a newly developed size-changeable collagenase-modified polymer micelle is employed… read more here.
Keywords: tumor tissue; penetration; collagenase; retention ... See more keywords
A Dendritic Polymer‐Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201200
Abstract: Nanoparticles (NPs)‐based cancer therapeutics are generally impeded by poor drug penetration into solid tumors due to their dense tumor extracellular matrix (ECM). Herein, pH/redox‐responsive dendritic polymer‐based NPs are developed to amplify the neighboring effect for… read more here.
Keywords: effect; penetration; dendritic polymer; neighboring effect ... See more keywords