Stroma content in triple-negative breast cancer spheroid models regulates penetration and efficacy of tumor-targeting Salmonella typhimurium
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-025-00770-7
Abstract: Bacteria-based cancer therapy (BBCT) has not yet conferred clinical survival advantages in solid tumors, partly due to limited colonization. Collagen is well-known to hinder the penetration and efficacy of many therapeutic modalities in solid tumors.… read more here.
Keywords: collagen; cancer; penetration efficacy; breast cancer ... See more keywords
Enhanced Skin Penetration and Efficacy: First and Second Generation Lipoidal Nanocarriers in Skin Cancer Therapy
Sign Up to like & getrecommendations! Published in 2024 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-024-02884-w
Abstract: Skin carcinoma remains one of the most widespread forms of cancer, and its global impact continues to increase. Basal cell carcinoma, melanoma, and squamous cell carcinoma are three kinds of cutaneous carcinomas depending upon occurrence… read more here.
Keywords: enhanced skin; cancer; skin penetration; therapy ... See more keywords
Influence of Massage and Skin Hydration on Dermal Penetration Efficacy of Nile Red from Petroleum Jelly—An Unexpected Outcome
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DOI: 10.3390/pharmaceutics13122190
Abstract: The study aimed at comparing the influence of direct and indirect skin hydration as well as massage on the dermal penetration efficacy of active compounds. Nile red was used as a lipophilic drug surrogate and… read more here.
Keywords: dermal penetration; penetration efficacy; skin hydration; penetration ... See more keywords
Assessing the Dermal Penetration Efficacy of Chemical Compounds with the Ex-Vivo Porcine Ear Model
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DOI: 10.3390/pharmaceutics14030678
Abstract: (1) Background: The ex vivo porcine ear model is often used for the determination of the dermal penetration efficacy of chemical compounds. This study investigated the influence of the post-slaughter storage time of porcine ears… read more here.
Keywords: penetration; chemical compounds; penetration efficacy; efficacy chemical ... See more keywords
Particle-Assisted Dermal Penetration—A Simple Formulation Strategy to Foster the Dermal Penetration Efficacy
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DOI: 10.3390/pharmaceutics14051039
Abstract: (1) Background: The study systematically investigated the influence of dispersed particles within a topical formulation on the dermal penetration efficacy of active compounds that are dissolved in the water phase of this formulation. The aim… read more here.
Keywords: formulation; penetration; penetration efficacy; particle assisted ... See more keywords
Influence of Mechanical Skin Treatments on Dermal Penetration Efficacy of Active Ingredients
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DOI: 10.3390/pharmaceutics14091788
Abstract: The effective dermal penetration of active ingredients (AI) is a major task in the formulation of topical products. Besides the vehicle, the mechanical skin treatments are also considered to impact the penetration efficacy of AI.… read more here.
Keywords: skin treatments; skin; penetration; penetration efficacy ... See more keywords