Enhanced Follicular Delivery of Finasteride to Human Scalp Skin Using Heat and Chemical Penetration Enhancers
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DOI: 10.1007/s11095-020-02822-y
Abstract: Purpose The aim of this work was to evaluate whether improved topical delivery of finasteride, focussed to the hair follicles of human scalp skin could be achieved with application of short durations of heat and… read more here.
Keywords: chemical penetration; penetration; human scalp; penetration enhancers ... See more keywords
Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
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DOI: 10.1039/c8ra04129f
Abstract: Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a… read more here.
Keywords: stratum corneum; penetration; lipid liposomes; penetration enhancers ... See more keywords
Monocyclic monoterpenes as penetration enhancers of ligustrazine hydrochloride for dermal delivery
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DOI: 10.1080/10837450.2016.1189936
Abstract: Abstract The purpose of this study was to explore the enhancing effects and the mechanism of monocyclic monoterpene penetration enhancers (menthol and menthone) on the transdermal absorption of ligustrazine hydrochloride (LH). Franz-type diffusion cells were… read more here.
Keywords: monoterpenes penetration; enhancers ligustrazine; penetration; penetration enhancers ... See more keywords
Essential Oils Distilled from Colombian Aromatic Plants and Their Constituents as Penetration Enhancers for Transdermal Drug Delivery
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DOI: 10.3390/molecules28062872
Abstract: The study aimed to determine the enhanced effects of essential oils (EOs) and plant-derived molecules (PDMs) as penetration enhancers (PEs) for transdermal drug delivery (TDD) of caffeine. A 1% w/w solution of eight EOs and… read more here.
Keywords: essential oils; transdermal drug; caffeine; penetration enhancers ... See more keywords
The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability
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DOI: 10.3390/pharmaceutics10040206
Abstract: Microspheres based on both methyl-β-cyclodextrins and chitosan were prepared by spray-drying as nasal formulations of a model polar drug to analyze, firstly, how the composition of the carrier affects drug permeation across synthetic membranes and,… read more here.
Keywords: nasal microspheres; role combined; combined penetration; drug ... See more keywords
Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review
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DOI: 10.3390/pharmaceutics13020276
Abstract: There is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical administration. Here, we systematically reviewed the literature on ocular penetration enhancers and… read more here.
Keywords: penetration; drug delivery; posterior segment; penetration enhancers ... See more keywords
Effect of Penetration Enhancers and Safety on the Transdermal Delivery of Apremilast in Skin
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DOI: 10.3390/pharmaceutics14051011
Abstract: The poor water solubility of apremilast (APR) is the main impediment to the penetration of the drug through the skin barrier. The objective of this study was to evaluate the permeability of APR in different… read more here.
Keywords: safety transdermal; skin; effect penetration; penetration ... See more keywords
Effect of Penetration Enhancers on Transdermal Delivery of Oxcarbazepine, an Antiepileptic Drug Using Microemulsions
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DOI: 10.3390/pharmaceutics15010183
Abstract: Oxcarbazepine (OXC) is an anticonvulsant drug, indicated for the treatment of the neurological disorder, epilepsy. The objective of the present study was to evaluate the transdermal delivery of OXC from microemulsions using different penetration enhancers.… read more here.
Keywords: effect penetration; penetration; penetration enhancers; transdermal delivery ... See more keywords
Formulation of Polymers-Based Methotrexate Patches and Investigation of the Effect of Various Penetration Enhancers: In Vitro, Ex Vivo and In Vivo Characterization
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DOI: 10.3390/polym14112211
Abstract: The present study aimed to prepare methotrexate-loaded transdermal patches with different blends of hydrophobic and hydrophilic polymers (Eudragit S-100 and hydroxypropyl methylcellulose) at different concentrations. The polymers employed in transdermal patches formulations served as controlled… read more here.
Keywords: formulation; methotrexate; penetration enhancers; drug ... See more keywords
Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations
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DOI: 10.3390/scipharm90010014
Abstract: Oils, including essential oils and their constituents, are widely reported to have penetration enhancement activity and have been incorporated into a wide range of pharmaceutical formulations. This study sought to determine if there is an… read more here.
Keywords: pharmaceutical formulations; carrier; essential oils; systematic review ... See more keywords