A Transformable Amphiphilic and Block Polymer−Dendron Conjugate for Enhanced Tumor Penetration and Retention with Cellular Homeostasis Perturbation via Membrane Flow
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DOI: 10.1002/adma.202200048
Abstract: Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design of drug delivery systems. Herein, a polymer−dendron conjugate, POEGMA‐b‐p(GFLG‐Dendron‐Ppa) (GFLG‐DP), is presented, which allows a cathepsin‐B‐triggered stealthy‐to‐sticky structural transformation.… read more here.
Keywords: penetration retention; tumor; dendron; membrane ... See more keywords