Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway.
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DOI: 10.1007/s13402-021-00620-1
Abstract: PURPOSE Metastasis of lung adenocarcinoma (LADC) is a crucial factor determining patient survival. Repurposing of the antipsychotic agent penfluridol has been found to be effective in the inhibition of growth of various cancers. As yet,… read more here.
Keywords: lung adenocarcinoma; ladc cells; mmp; metastasis ... See more keywords
Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer
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DOI: 10.3390/cancers14112750
Abstract: Simple Summary Drug repurposing has been effective for discovering novel treatments for cancer. The antipsychotic agent penfluridol was reported to suppress lung cancer growth via ATP energy deprivation. The aim of our study was to… read more here.
Keywords: lung cancer; inhibition; energy; penfluridol ... See more keywords