A self-immolative linker that releases thiols detects penicillin amidase and nitroreductase with high sensitivity via absorption spectroscopy.
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DOI: 10.1039/d1cc05322a
Abstract: This article reports the synthesis and characterization of a novel self-immolative linker, based on thiocarbonates, which releases a free thiol upon activation via enzymes. We demonstrate that thiocarbonate self-immolative linkers can be used to detect… read more here.
Keywords: immolative linker; penicillin amidase; high sensitivity; spectroscopy ... See more keywords