Exposure to β-lactams results in the alteration of penicillin-binding proteins in Clostridium perfringens.
Sign Up to like & getrecommendations! Published in 2017 at "Anaerobe"
DOI: 10.1016/j.anaerobe.2017.02.004
Abstract: Clostridium perfringens causes a variety of mild to severe infections in humans and other animals. A decrease in the affinity of penicillin-binding protein (PBP) transpeptidases for β-lactams is considered one of the mechanisms of β-lactam… read more here.
Keywords: clostridium perfringens; exposure lactams; penicillin; lactams results ... See more keywords
Antimicrobial resistance, penicillin-binding protein sequences, and pilus islet carriage in relation to clonal evolution of Streptococcus pneumoniae serotype 19A in Russia, 2002–2013
Sign Up to like & getrecommendations! Published in 2017 at "Epidemiology and Infection"
DOI: 10.1017/s0950268817000541
Abstract: SUMMARY Clonal changes of serotype 19A pneumococci have been appreciated in conjunction with growing prevalence of this serotype after implementation of the seven-valent pneumococcal conjugate vaccine (PCV7). In the present study, we characterized serotype 19A… read more here.
Keywords: clonal evolution; 2002 2013; islet carriage; serotype 19a ... See more keywords
Decoding the Penicillin-Binding Proteins with Activity-Based Probes.
Sign Up to like & getrecommendations! Published in 2025 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.5c00113
Abstract: ConspectusThe bacterial cell wall is a complex structure that is primarily composed of peptidoglycan (PG), which provides protection from the environment and structural rigidity for the cell. As such, PG plays an important role in… read more here.
Keywords: penicillin binding; binding proteins; cell; activity based ... See more keywords
Nonlocal Effects of Antibiotic-Resistance-Causing Mutations Reveal an Alternative Region for Targeting on FtsW-Penicillin-Binding Protein 3 Complex of Haemophilus influenzae
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00127
Abstract: Currently prescribed antibiotics target the catalytic sites of wild-type bacterial proteins; however, bacteria adopt mutations at this site, eventually leading to the emergence of resistance. Therefore, the identification of alternative drug binding sites is crucial,… read more here.
Keywords: binding protein; haemophilus influenzae; resistance causing; resistance ... See more keywords
Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of Streptococcus pneumoniae Penicillin-Binding Protein 2x.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c02273
Abstract: The allosteric site of penicillin-binding protein 2x (PBP2x), an essential enzyme of cell-wall biosynthesis of Streptococcus pneumoniae, was targeted in virtual screening of >2 M compounds. A benzimidazole-2-methanamine hit emerged, which exhibited a modest minimal-inhibitory… read more here.
Keywords: penicillin binding; antibacterial benzimidazole; benzimidazole methanamines; streptococcus pneumoniae ... See more keywords
Live-Cell Profiling of Penicillin-Binding Protein Inhibitors in Escherichia coli MG1655.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00004
Abstract: Penicillin-binding proteins (PBPs) make up an essential class of bacterial enzymes that carry out the final steps of peptidoglycan synthesis and regulate the recycling of this polymeric structure. PBPs are an excellent drug target and… read more here.
Keywords: escherichia coli; coli mg1655; live cell; pbp ... See more keywords
Identification of a Functionally Unique Family of Penicillin-Binding Proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10170
Abstract: Penicillin-binding proteins (PBPs) are enzymes involved in the assembly of the bacterial cell wall, a major target for antibiotics. These proteins are classified by mass into high-molecular-weight PBPs, which are transpeptidases that form peptidoglycan cross-links,… read more here.
Keywords: unique family; binding proteins; functionally unique; penicillin binding ... See more keywords
Structural basis of Pseudomonas aeruginosa penicillin binding protein 3 inhibition by the siderophore-antibiotic cefiderocol
Sign Up to like & getrecommendations! Published in 2024 at "Chemical Science"
DOI: 10.1039/d4sc04937c
Abstract: The breakthrough cephalosporin cefiderocol, approved for clinical use in 2019, has activity against many Gram-negative bacteria. The catechol group of cefiderocol enables it to efficiently enter bacterial cells via the iron/siderophore transport system thereby reducing… read more here.
Keywords: penicillin binding; pseudomonas aeruginosa; inhibition; cefiderocol ... See more keywords
Phyllosticta capitalensis: a novel source of Guignardone A, a high-affinity ligand for penicillin-binding proteins.
Sign Up to like & getrecommendations! Published in 2025 at "Natural product research"
DOI: 10.1080/14786419.2025.2509879
Abstract: Endophytic fungi from Pleurolobus gangeticus were isolated, clone purified, identified and subjected to liquid state fermentation. Ethyl acetate extracts of the fermentation product was prepared for antibacterial testing against gram-negative and gram-positive bacteria. Out of… read more here.
Keywords: penicillin binding; guignardone; capitalensis; phyllosticta capitalensis ... See more keywords
Modification of the penicillin-binding-protein 3 as a source of resistance to broad-spectrum cephalosporins in Escherichia coli
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkae020
Abstract: Multidrug-resistant Gram-negative bacteria are one of the major threats to human health, largely due to the dissemination of some high-risk successful multidrug-resistant clones. 1 Of particular concern is the resistance to ß-lactams, because those antibiotics… read more here.
Keywords: penicillin binding; modification penicillin; resistance; protein source ... See more keywords
Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial genomics"
DOI: 10.1099/mgen.0.000622
Abstract: Streptococcus pneumoniae is an important global pathogen that causes bacterial pneumonia, sepsis and meningitis. Beta-lactam antibiotics are the first-line treatment for pneumococcal disease, however, their effectiveness is hampered by beta-lactam resistance facilitated by horizontal genetic… read more here.
Keywords: streptococcus pneumoniae; mitis; penicillin binding; binding protein ... See more keywords