Exposure to β-lactams results in the alteration of penicillin-binding proteins in Clostridium perfringens.
Sign Up to like & getrecommendations! Published in 2017 at "Anaerobe"
DOI: 10.1016/j.anaerobe.2017.02.004
Abstract: Clostridium perfringens causes a variety of mild to severe infections in humans and other animals. A decrease in the affinity of penicillin-binding protein (PBP) transpeptidases for β-lactams is considered one of the mechanisms of β-lactam… read more here.
Keywords: clostridium perfringens; exposure lactams; penicillin; lactams results ... See more keywords
Antimicrobial resistance, penicillin-binding protein sequences, and pilus islet carriage in relation to clonal evolution of Streptococcus pneumoniae serotype 19A in Russia, 2002–2013
Sign Up to like & getrecommendations! Published in 2017 at "Epidemiology and Infection"
DOI: 10.1017/s0950268817000541
Abstract: SUMMARY Clonal changes of serotype 19A pneumococci have been appreciated in conjunction with growing prevalence of this serotype after implementation of the seven-valent pneumococcal conjugate vaccine (PCV7). In the present study, we characterized serotype 19A… read more here.
Keywords: clonal evolution; 2002 2013; islet carriage; serotype 19a ... See more keywords
Nonlocal Effects of Antibiotic-Resistance-Causing Mutations Reveal an Alternative Region for Targeting on FtsW-Penicillin-Binding Protein 3 Complex of Haemophilus influenzae
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00127
Abstract: Currently prescribed antibiotics target the catalytic sites of wild-type bacterial proteins; however, bacteria adopt mutations at this site, eventually leading to the emergence of resistance. Therefore, the identification of alternative drug binding sites is crucial,… read more here.
Keywords: binding protein; haemophilus influenzae; resistance causing; resistance ... See more keywords
Live-Cell Profiling of Penicillin-Binding Protein Inhibitors in Escherichia coli MG1655.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00004
Abstract: Penicillin-binding proteins (PBPs) make up an essential class of bacterial enzymes that carry out the final steps of peptidoglycan synthesis and regulate the recycling of this polymeric structure. PBPs are an excellent drug target and… read more here.
Keywords: escherichia coli; coli mg1655; live cell; pbp ... See more keywords
Identification of a Functionally Unique Family of Penicillin-Binding Proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10170
Abstract: Penicillin-binding proteins (PBPs) are enzymes involved in the assembly of the bacterial cell wall, a major target for antibiotics. These proteins are classified by mass into high-molecular-weight PBPs, which are transpeptidases that form peptidoglycan cross-links,… read more here.
Keywords: unique family; binding proteins; functionally unique; penicillin binding ... See more keywords
Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial genomics"
DOI: 10.1099/mgen.0.000622
Abstract: Streptococcus pneumoniae is an important global pathogen that causes bacterial pneumonia, sepsis and meningitis. Beta-lactam antibiotics are the first-line treatment for pneumococcal disease, however, their effectiveness is hampered by beta-lactam resistance facilitated by horizontal genetic… read more here.
Keywords: streptococcus pneumoniae; mitis; penicillin binding; binding protein ... See more keywords
Specific mutations of penicillin‐binding protein 1A in 77 clinically acquired amoxicillin‐resistant Helicobacter pylori strains in comparison with 77 amoxicillin‐susceptible strains
Sign Up to like & getrecommendations! Published in 2017 at "Helicobacter"
DOI: 10.1111/hel.12437
Abstract: Amoxicillin (Amx) is one of the most important antibiotics for eradication of Helicobacter pylori (H. pylori). Main determinants of genetically stable Amx resistance are mutations in the C‐terminus of penicillin‐binding protein 1A (pbp1A). However, contribution… read more here.
Keywords: helicobacter; binding protein; helicobacter pylori; penicillin binding ... See more keywords
Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01603-22
Abstract: The β-lactam antibiotics have been successfully used for decades to combat susceptible Pseudomonas aeruginosa, which has a notoriously difficult to penetrate outer membrane (OM). However, there is a dearth of data on target site penetration… read more here.
Keywords: pseudomonas aeruginosa; pharmacology; intact bacteria; penicillin binding ... See more keywords
Unipolar Peptidoglycan Synthesis in the Rhizobiales Requires an Essential Class A Penicillin-Binding Protein
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.02346-21
Abstract: While the structure and function of the bacterial cell wall are well conserved, the mechanisms responsible for cell wall biosynthesis during elongation are variable. It is increasingly clear that rod-shaped bacteria use a diverse array… read more here.
Keywords: penicillin binding; cell wall; elongation; growth ... See more keywords
Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00039-22
Abstract: M. tuberculosis, the causative agent of tuberculosis, kills more humans than any other bacterium. β-lactams are the most widely used class of antibiotics to treat bacterial infections. Unlike in the historical model that describes the… read more here.
Keywords: relationship lactams; tuberculosis; binding proteins; penicillin binding ... See more keywords
Detection and analysis of Lactobacillus paracasei penicillin-binding proteins revealed the presence of cholate-sensitive penicillin-binding protein 3 and an elongated cell shape in a cholate-sensitive strain
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience of Microbiota, Food and Health"
DOI: 10.12938/bmfh.16-019
Abstract: Penicillin-binding proteins (PBPs) are responsible for peptidoglycan synthesis. By using biotinylated ampicillin, we detected PBPs of Lactobacillus paracasei strains. Ten PBPs were identified, 7 of which had apparent molecular sizes similar to those of Escherichia… read more here.
Keywords: lactobacillus paracasei; binding proteins; cholate sensitive; penicillin ... See more keywords