Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202509742
Abstract: Penile squamous cell carcinoma (PSCC) is a malignancy characterized by a poor prognosis and lack of reliable biomarkers, presenting considerable therapeutic challenges. Tertiary lymphoid structures (TLSs) are critical modulators of antitumor immunity; however, the immunological… read more here.
Keywords: tertiary lymphoid; penile squamous; cell carcinoma; cell ... See more keywords
Get insight into the cause of death distribution and epidemiology of penile squamous cell carcinoma: A population-based study.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4614
Abstract: BACKGROUND Penile squamous cell carcinoma (PSCC) survival had no significant improvement since 1990 in the United States. This study aims to get insight into the changing trend and distribution of death causes of PSCC. The… read more here.
Keywords: epidemiology; pscc; penile squamous; cell carcinoma ... See more keywords
Immune-checkpoint status in penile squamous cell carcinoma: a North American cohort.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2016.09.003
Abstract: Penile squamous cell carcinoma (SCC) is primarily treated by surgical resection. Locally advanced and metastatic diseases require a multidisciplinary treatment approach. However, mortality and morbidity remain high, and novel molecular and immunotherapeutic targets are actively… read more here.
Keywords: immune checkpoint; penile squamous; pathology; expression ... See more keywords
Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64014-3
Abstract: Equine penile squamous cell carcinoma (EpSCC) is a relatively common cutaneous neoplasm with a poor prognosis. In this study, we aimed to determine the protein expression and colocalisation of FRA1, c-Myc, Cyclin D1, and MMP7… read more here.
Keywords: penile squamous; cell carcinoma; squamous cell; equine penile ... See more keywords
A study into the association between local recurrence rates and surgical resection margins in organ‐sparing surgery for penile squamous cell cancer
Sign Up to like & getrecommendations! Published in 2018 at "BJU International"
DOI: 10.1111/bju.14222
Abstract: To evaluate the significance of close surgical margins in organ‐sparing surgery (OSS) in the treatment of penile squamous cell carcinoma (pSCC) and clinicopathological factors that may influence local recurrence. read more here.
Keywords: margins organ; organ sparing; penile squamous; squamous cell ... See more keywords
Trophoblast cell surface antigen‐2: a promising new biomarker and potential therapeutic target in penile squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "BJU International"
DOI: 10.1111/bju.16442
Abstract: To evaluate the potential utility of antibody‐drug conjugates targeting trophoblast cell surface antigen‐2 (TROP‐2) in patients with primary penile squamous cell carcinoma (PSCC), patients with recurrence (REC cohort), and patient‐matched distant metastases (MET cohort), and… read more here.
Keywords: surface antigen; cell surface; penile squamous; trophoblast cell ... See more keywords
Metastatic penile squamous cell carcinoma with dramatic response to combined checkpoint blockade with ipilimumab and nivolumab
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155220922602
Abstract: Introduction Prognosis for patients with lymph node positive or metastatic penile squamous cell carcinoma remains poor. Chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP regimen) is recommended as a first-line option in this cohort of patients.… read more here.
Keywords: penile; response; penile squamous; cell carcinoma ... See more keywords
A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma
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DOI: 10.1186/s12894-024-01532-6
Abstract: Background We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC). Methods We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides… read more here.
Keywords: cell carcinoma; structure; squamous cell; penile squamous ... See more keywords
Treatment patterns and outcomes of patients with penile squamous-cell carcinoma (PSCC) undergoing inguinal lymph node dissection (ILND): An analysis of a multicenter contemporary database.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.5585
Abstract: 5585Background: PSCC is a rare tumor and the administration of guidelines-based therapies is still problematic in real-world practice. Survival outcomes remain suboptimal in patients (pts) with ILN... read more here.
Keywords: outcomes patients; penile squamous; patterns outcomes; patients penile ... See more keywords
p16INK4a expression and survival outcomes in patients with penile squamous cell carcinoma: The M.D. Anderson Cancer Center Experience.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.5
Abstract: 5Background: Penile Squamous Cell Carcinoma (PSCC) is associated with high risk human papillomavirus (HR-HPV) in about 50% of cases. The immunohistochemical test for p16INK4a (p16) is highly correl... read more here.
Keywords: cell carcinoma; squamous cell; p16ink4a expression; penile squamous ... See more keywords
Immune checkpoint inhibitor plus anti-EGFR target therapy plus chemotherapy in patients with locally advanced penile squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e17016
Abstract: e17016Background: Locally advanced penile squamous cell carcinomas (PSCCs) have poor prognosis and limited therapeutic options. We aim to evaluate the safety and the efficacy of neoadjuvant therapy... read more here.
Keywords: penile squamous; therapy; locally advanced; squamous cell ... See more keywords