Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00482
Abstract: The difficulty in treating Gram-negative bacteria can largely be attributed to their highly impermeable outer membrane (OM), which serves as a barrier to many otherwise active antibiotics. This can be overcome with the use of… read more here.
Keywords: development; preclinical development; pentamidine; antibiotic adjuvant ... See more keywords
The selective response of a templated polymer for the cationic drug pentamidine: implications from molecular simulations and experimental data
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra07590a
Abstract: In this paper, we present an analysis of the surface modifications responsible for the selectivity of a new imprinted sorbent produced for the isolation of pentamidine cations. We examined the polymers formed from acrylic acid… read more here.
Keywords: pentamidine; polymer cationic; response templated; selective response ... See more keywords
Therapeutic potential of pentamidine for glioma-initiating cells and glioma cells through multimodal antitumor effects.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15827
Abstract: Glioma-initiating cells, which comprise a heterogeneous population of glioblastomas, contribute to resistance against aggressive chemoradiotherapy. Using drug reposition, we investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that… read more here.
Keywords: pentamidine; glioma initiating; glioma; initiating cells ... See more keywords
When Combined with Pentamidine, Originally Ineffective Linezolid Becomes Active in Carbapenem-Resistant Enterobacteriaceae
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03138-22
Abstract: The multidrug resistance and biofilm formation of Gram-negative bacteria (GNB) may lead to incurable “superbug” infections. Drug combinations, with the potential to augment the original treatment ranges of drugs, are alternative treatment strategies against GNB.… read more here.
Keywords: carbapenem resistant; combination; pentamidine; treatment ... See more keywords
Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)
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DOI: 10.1371/journal.pone.0173474
Abstract: Pentamidine is an effective trypanocidal drug used against stage 1 Human African Trypanosomiasis (HAT). At the blood-brain barrier (BBB), it accumulates inside the endothelial cells but has limited entry into the brain. This study examined… read more here.
Keywords: pentamidine; accumulation; blood brain; bbb ... See more keywords
Repurposing pentamidine for cancer immunotherapy by targeting the PD1/PD-L1 immune checkpoint
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1145028
Abstract: Immunotherapy has emerged as an effective therapeutic approach to several cancer types. The reinvigoration of tumor-infiltrating lymphocyte-mediated immune responses via the blockade of immune checkpoint markers, such as program cell death-1 (PD-1) or its cognate… read more here.
Keywords: immune checkpoint; pentamidine; tumor; cancer ... See more keywords
Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.835081
Abstract: Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that can recognize lipopolysaccharides (LPS) and initiate the immune response, to protect the body from infection. However, excessive activation of TLR4 induced by LPS leads to… read more here.
Keywords: tlr4; sepsis; activation; pentamidine ... See more keywords
In Vitro Evaluation of Aerosol Therapy with Pentamidine-Loaded Liposomes Coated with Chondroitin Sulfate or Heparin for the Treatment of Leishmaniasis
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041163
Abstract: The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity. We sought to test the potential… read more here.
Keywords: pentamidine; aerosol therapy; heparin; treatment leishmaniasis ... See more keywords