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Synthesis of pentasubstituted 2-aryl pyrroles from boryl and stannyl alkynes via one-pot sequential Ti-catalyzed [2 + 2 + 1] pyrrole synthesis/cross coupling reactions†

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0 Published in 2020 at "Chemical Science"

DOI: 10.1039/d0sc01576h

Abstract: Multisubstituted pyrroles are commonly found in many bioactive small molecule scaffolds, yet the synthesis of highly-substituted pyrrole cores remains challenging. Herein, we report an efficient catalytic synthesis of 2-heteroatom-substituted (9-BBN or SnR3) pyrroles via Ti-catalyzed… read more here.

Keywords: coupling reactions; aryl pyrroles; pentasubstituted aryl; one pot ... See more keywords