Comparative study of dezocine, pentazocine and tapentadol on antinociception and physical dependence.
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DOI: 10.1016/j.lfs.2021.119996
Abstract: AIMS Dezocine and pentazocine, widely prescribed in China for postoperative pain, were initially considered as mixed agonist/antagonist targeting μ-opioid receptors (MORs) and κ-opioid receptors (KORs). However, dezocine has been revealed to alleviate chronic neuropathic pain… read more here.
Keywords: pentazocine; dezocine pentazocine; tapentadol; antinociception ... See more keywords
Negative modulation of spinal κ-opioid receptor-mediated antinociception by the µ-opioid receptor at selective doses of (−)-pentazocine
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DOI: 10.1097/wnr.0000000000001043
Abstract: The mixed-action &kgr;-opioid receptor (KOR) agonist, pentazocine, binds to both KOR and the µ-opioid receptor (MOR). Racemic (±)-pentazocine and (−)-pentazocine, each administered systemically, have been shown to produce antinociception in various animal models. In contrast,… read more here.
Keywords: pentazocine; antinociception; opioid receptor; mor ... See more keywords