Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP‐3
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13556
Abstract: Extracellular levels of soluble TIMP‐3 are low, reflecting its binding by extracellular matrix (ECM) components including sulfated glycosaminoglycans (SGAGs) and endocytosis via low density lipoprotein receptor‐related protein 1. Since TIMP‐3 inhibits ECM degradation, the ability… read more here.
Keywords: domain timp; chondroitin sulfate; timp; sulfate pentosan ... See more keywords
Repurposing pentosan polysulfate sodium as hyaluronic acid linked polyion complex nanoparticles for the management of osteoarthritis: A potential approach.
Sign Up to like & getrecommendations! Published in 2021 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2021.110713
Abstract: Osteoarthritis is still a disease burden for pharmaceutical scientists and strategy makers. It is associated with the chronic inflammation of joints especially weight-bearing joints like knee, hip, backbone, and phalanges. NSAIDs that are used for… read more here.
Keywords: polyion complex; management; hyaluronic acid; acid linked ... See more keywords
Pigmentary Maculopathy Associated with Chronic Exposure to Pentosan Polysulfate Sodium.
Sign Up to like & getrecommendations! Published in 2018 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2018.04.026
Abstract: PURPOSE To describe the clinical features of a unique pigmentary maculopathy noted in the setting of chronic exposure to pentosan polysulfate sodium (PPS), a therapy for interstitial cystitis (IC). DESIGN Retrospective case series. PARTICIPANTS Six… read more here.
Keywords: exposure pentosan; exposure; pigmentary maculopathy; pentosan polysulfate ... See more keywords
Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2018.11.028
Abstract: Pentosan polysulfate (PPS) is currently under investigation as a potential disease-modifying antiarthritic agent. In the present study the effects of PPS on arthritic profiles based on clinical score, ankle size, histological changes, and activity of… read more here.
Keywords: induced arthritis; anti arthritic; arthritic rats; collagen induced ... See more keywords
Prevalence and Dose Dependency Analysis of Pentosan Polysulfate Sodium Maculopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic epidemiology"
DOI: 10.1080/09286586.2022.2031227
Abstract: PURPOSE We describe a retrospective cohort study investigating the prevalence of pentosan polysulfate sodium (PPS) maculopathy in patients with PPS exposure, as well as the relationship between cumulative PPS exposure and the presence of PPS-maculopathy.… read more here.
Keywords: exposure; pps; dose; pentosan polysulfate ... See more keywords
Case Report: Pentosan Polysulfate Sodium Maculopathy Originally Diagnosed as Pattern Macular Dystrophy
Sign Up to like & getrecommendations! Published in 2021 at "Optometry and Vision Science"
DOI: 10.1097/opx.0000000000001702
Abstract: SIGNIFICANCE Pentosan polysulfate sodium (PPS) maculopathy is a clinical entity characterized by a pigmentary maculopathy in the setting of chronic exposure to PPS. Pentosan polysulfate sodium is indicated for discomfort related to interstitial cystitis/painful bladder… read more here.
Keywords: diagnosed pattern; pattern macular; pentosan polysulfate; case report ... See more keywords
Risk of maculopathy with pentosan polysulfate sodium use
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15303
Abstract: Recent epidemiologic studies have examined the risk of maculopathy with pentosan polysulfate sodium (PPS), a drug indicated for the treatment of interstitial cystitis. However, results have been contradictory. Thus, we quantified the risk of maculopathy… read more here.
Keywords: polysulfate sodium; pentosan polysulfate; maculopathy pentosan; risk maculopathy ... See more keywords
Pentosan polysulfate regulates hepcidin 1-facilitated formation and function of osteoclast derived from canine bone marrow
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265596
Abstract: Hepcidin which is the crucial regulator of iron homeostasis, produced in the liver in response to anemia, hypoxia, or inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis by inhibiting… read more here.
Keywords: function; pps; pentosan polysulfate; iron ... See more keywords
Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020258
Abstract: With the increased prevalence of new SARS-CoV-2 variants of concern, such as Delta and Omicron, the COVID-19 pandemic has become an ongoing human health disaster, killing millions worldwide. SARS-CoV-2 invades its host through the interaction… read more here.
Keywords: polysulfate; pentosan polysulfate; heparin; anti sars ... See more keywords
Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030437
Abstract: Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional… read more here.
Keywords: pps; protection multiple; pentosan polysulfate; affords pleotropic ... See more keywords
Pentosan polysulfate maculopathy: a brief primer for general practitioners, ophthalmologists, optometrists and urologists
Sign Up to like & getrecommendations! Published in 2023 at "Medical Journal of Australia"
DOI: 10.5694/mja2.51913
Abstract: A 55yearold woman in the United States, with a history of interstitial cystitis diagnosed at age 33 years, was referred for pattern macular dystrophy. Her primary complaint was difficulty reading, despite using bifocals. Her medications… read more here.
Keywords: primer general; general practitioners; pentosan polysulfate; maculopathy brief ... See more keywords