Articles with "pentose phosphate" as a keyword



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High‐Z‐Sensitized Radiotherapy Synergizes with the Intervention of the Pentose Phosphate Pathway for In Situ Tumor Vaccination

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Published in 2022 at "Advanced Materials"

DOI: 10.1002/adma.202109726

Abstract: In situ tumor vaccination is preliminarily pursued to strengthen antitumor immune response. Immunogenic tumor cell death spontaneously releases abundant antigens and adjuvants for activation of dendritic cells, providing a paragon opportunity for establishing efficient in… read more here.

Keywords: phosphate pathway; vaccination; pentose phosphate; tumor vaccination ... See more keywords
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Methyl benzoate derivatives as inhibitors of pentose phosphate pathway, which promotes cancer progression and drug resistance: An In Silico study supported By In Vitro results.

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Published in 2022 at "Biotechnology and applied biochemistry"

DOI: 10.1002/bab.2322

Abstract: The pentose phosphate pathway (PPP), whose products are vital in biosynthetic events, is targeted in the treatment of many diseases such as cancer and malaria. The objective of this study was to identify new PPP… read more here.

Keywords: cancer; study; phosphate pathway; pentose phosphate ... See more keywords
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Disorders in NADPH generation via pentose phosphate pathway influence the reproductive potential of the Saccharomyces cerevisiae yeast due to changes in redox status

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Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.28140

Abstract: Intermediary metabolites have a crucial impact on basic cell functions. There is a relationship between cellular metabolism and redox balance. To maintain redox homoeostasis, the cooperation of both glutathione and nicotine adenine dinucleotides is necessary.… read more here.

Keywords: phosphate pathway; pentose phosphate; disorders nadph; physiology ... See more keywords
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Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13C‐isotopomers derived from [U‐13C]fructose and [U‐13C]glucose

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Published in 2020 at "Magnetic Resonance in Medicine"

DOI: 10.1002/mrm.28286

Abstract: The pentose phosphate pathway (PPP) is an important component of hepatic intermediary metabolism. Jin et al developed an elegant 13C‐NMR method for measuring hepatic PPP flux by quantifying the distribution of glucose 13C‐isotopomers formed from… read more here.

Keywords: phosphate pathway; fructose 13c; pentose phosphate; 13c isotopomers ... See more keywords
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Neuroprotective Mechanism of Hypoxic Post-conditioning Involves HIF1-Associated Regulation of the Pentose Phosphate Pathway in Rat Brain

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Published in 2018 at "Neurochemical Research"

DOI: 10.1007/s11064-018-2681-x

Abstract: Post-conditioning is exposure of an injured organism to the same harmful factors but of milder intensity which mobilizes endogenous protective mechanisms. Recently, we have developed a novel noninvasive post-conditioning (PostC) protocol involving three sequential episodes… read more here.

Keywords: post conditioning; involves hif1; phosphate pathway; pentose phosphate ... See more keywords
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Influence of 6-aminonicotinamide (6AN) on Leishmania promastigotes evaluated by metabolomics: Beyond the pentose phosphate pathway.

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Published in 2018 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2018.08.014

Abstract: 6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. It is converted by a NAD(P)+ glycohydrolase to 6-aminoNAD and… read more here.

Keywords: phosphate pathway; pentose phosphate; leishmania promastigotes; aminonicotinamide 6an ... See more keywords
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Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.

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Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.01.013

Abstract: Reactive oxygen species (ROS) play critical roles in metabolism and disease, yet a comprehensive analysis of the cellular response to oxidative stress is lacking. To systematically identify regulators of oxidative stress, we conducted genome-wide Cas9/CRISPR and shRNA… read more here.

Keywords: phosphate pathway; regulators oxidative; pentose phosphate; import ... See more keywords
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Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory

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Published in 2021 at "Cell Reports"

DOI: 10.1016/j.celrep.2021.109620

Abstract: Summary Brain function relies almost solely on glucose as an energy substrate. The main model of brain metabolism proposes that glucose is taken up and converted into lactate by astrocytes to fuel the energy-demanding neuronal… read more here.

Keywords: term memory; phosphate pathway; long term; pentose phosphate ... See more keywords
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Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress.

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Published in 2018 at "Cell systems"

DOI: 10.1016/j.cels.2018.04.009

Abstract: To counteract oxidative stress and reactive oxygen species (ROS), bacteria evolved various mechanisms, primarily reducing ROS through antioxidant systems that utilize cofactor NADPH. Cells must stabilize NADPH levels by increasing flux through replenishing metabolic pathways… read more here.

Keywords: capacity; phosphate pathway; pentose phosphate; stress ... See more keywords
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Silencing of the pentose phosphate pathway genes influences DNA replication in human fibroblasts.

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Published in 2017 at "Gene"

DOI: 10.1016/j.gene.2017.09.005

Abstract: Previous reports and our recently published data indicated that some enzymes of glycolysis and the tricarboxylic acid cycle can affect the genome replication process by changing either the efficiency or timing of DNA synthesis in… read more here.

Keywords: phosphate pathway; pentose phosphate; dna replication; pathway ... See more keywords
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Trans-omic Analysis Reveals ROS-Dependent Pentose Phosphate Pathway Activation after High-Frequency Electrical Stimulation in C2C12 Myotubes

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Published in 2020 at "iScience"

DOI: 10.1016/j.isci.2020.101558

Abstract: Summary Skeletal muscle adaptation is mediated by cooperative regulation of metabolism, signal transduction, and gene expression. However, the global regulatory mechanism remains unclear. To address this issue, we performed electrical pulse stimulation (EPS) in differentiated… read more here.

Keywords: high frequency; frequency; pentose phosphate; trans omic ... See more keywords