Pain Prevalence, Characteristics, and Impact Among People with Hemophilia: Findings from the First Portuguese Survey and Implications for Pain Management.
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DOI: 10.1093/pm/pny309
Abstract: BACKGROUND Hemophilia is a rare disorder characterized by spontaneous bleeding, with pain being a critical aspect. However, a systematic assessment of hemophilia-related pain in Portugal has never been conducted. OBJECTIVE To understand the pain experience… read more here.
Keywords: prevalence characteristics; characteristics impact; people hemophilia; children teenagers ... See more keywords
A randomized trial of safety, pharmacokinetics and pharmacodynamics of concizumab in people with hemophilia A
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DOI: 10.1111/jth.14272
Abstract: Essentials explorer™3 was a double‐blinded, multiple‐dose escalation trial of subcutaneous concizumab. A pharmacodynamic relationship for unbound TFPI and thrombin generation was confirmed. No serious adverse events and no anti‐drug antibodies were observed. explorer™3 data support… read more here.
Keywords: trial safety; concizumab people; randomized trial; safety pharmacokinetics ... See more keywords
Safety first: Tracking adverse events associated with new therapies for people with hemophilia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15188
Abstract: The year 1992 was momentous for individuals affected by hemophilia. Eight years after the successful cloning of the factor VIII gene and 5 years after clinical trials assessing the safety and efficacy of recombinant factor… read more here.
Keywords: recombinant factor; safety; factor viii; food drug ... See more keywords