Esterase mutation is a mechanism of resistance to antimalarial compounds
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DOI: 10.1038/ncomms14240
Abstract: Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured Plasmodium falciparum is highly variable depending on the commercial source. Here we identify a… read more here.
Keywords: mutation mechanism; resistance; esterase mutation; pepstatin ... See more keywords