Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule.
Sign Up to like & getrecommendations! Published in 2022 at "Amino acids"
DOI: 10.1007/s00726-022-03154-4
Abstract: Hypertension is a major risk factor for kidney and cardiovascular disease. The treatment of hypertensive individuals by selected ACE inhibitors and certain di-and tripeptides halts the progression of renal deterioration and extends life-span. Renal reabsorption… read more here.
Keywords: pept1 pept2; expression; proximal tubule; hypertension ... See more keywords
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2129517
Abstract: Abstract Mirogabalin is a α2δ ligand as well as pregabalin. The aim of this study was to clarify whether mirogabalin is a substrate of human LAT1, which involved in absorption and disposition of pregabalin, and… read more here.
Keywords: oat3 oct2; oct2; mirogabalin; pept1 pept2 ... See more keywords