Acaciain peptidase: The first South American pollen peptidase potentially involved in respiratory allergy
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1837
Abstract: Acacia caven (Mol.) Molina pollen causes pollinosis in South America. The aim of this work was to isolate, purify, and characterize the proteolytic enzymes of A. caven pollen, and study their influence on allergy. A… read more here.
Keywords: acaciain peptidase; peptidase first; first south; peptidase ... See more keywords
Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-4
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2062-4
Abstract: A novel series of pyridine-based derivatives was synthesized and evaluated for their inhibitory activity against dipeptidyl peptidase-4 (DPP4). 5-Aminomethyl-6-(2,4-dichlorophenyl)-4-[(1H-1,2,4-triazol-1-yl)methyl]pyridine-2-carboxylic acid was identified as a potent (IC50 0.57 nM) and selective DPP4 inhibitor (DPP8/DPP4 = 238).… read more here.
Keywords: phenylpyridine derivatives; biological evaluation; peptidase; synthesis phenylpyridine ... See more keywords
Signal peptidase I processed secretory signal sequences: Selection for and against specific amino acids at the second position of mature protein.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.044
Abstract: Signal peptides direct proteins from the cytoplasm to the periplasm. These N-terminal peptides are cleaved upon entry to the periplasm by either signal peptidase I, or signal peptidase II for lipoproteins. Signal peptidase I is… read more here.
Keywords: amino acids; position; signal peptidase; peptidase ... See more keywords
Fish skin gelatin hydrolysates produced by visceral peptidase and bovine trypsin: Bioactivity and stability.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.07.145
Abstract: The peptidase from the viscera of farmed giant catfish was used for producing gelatin hydrolysates (HG) and compared with those produced from commercial bovine trypsin (HB). The degree of hydrolysis (DH) observed suggests that proteolytic… read more here.
Keywords: visceral peptidase; gelatin hydrolysates; bovine trypsin; peptidase ... See more keywords
General Strategy for Bioluminescence Sensing of Peptidase Activity In Vivo Based on Tumor-Targeting Probiotic.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c00093
Abstract: The abnormally expressed peptidases in human tissues are associated with many kinds of cancers. Monitoring of endogenous peptidase activity could allow us for pathophysiology elucidation and early clinical diagnosis. Herein, we developed a general strategy… read more here.
Keywords: sensing peptidase; peptidase activity; peptidase; strategy ... See more keywords
Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00700
Abstract: The RiPP precursor recognition element (RRE) is a conserved domain found in many prokaryotic ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic gene clusters (BGCs). RREs bind with high specificity and affinity to a recognition… read more here.
Keywords: recognition; peptidase; rre; leader ... See more keywords
Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-75288-y
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP4i) are antidiabetic medications that prevent cleavage of incretin hormones by dipeptidyl peptidase-4 (DPP4). DPP4 is ubiquitously expressed, and its hepatic DPP4 expression is upregulated under non-alcoholic steatohepatitis (NASH) conditions. We investigated… read more here.
Keywords: trail receptor; peptidase; expression; mice ... See more keywords
Accurate and sensitive detection of dipeptidyl peptidase-IV activity by liquid chromatography with fluorescence detection
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Methods"
DOI: 10.1039/c9ay02610j
Abstract: Dipeptidyl peptidase-IV (DPP-IV), an important prolyl-specific peptidase in the serine hydrolase family, hydrolyzes a large number of endogenous oligopeptides. In clinical studies, the detection of DPP-IV, especially the detection of its activity, is particularly important.… read more here.
Keywords: detection; fluorescence; method; dpp ... See more keywords
An activity-based probe targeting the streptococcal virulence factor C5a peptidase.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01517j
Abstract: Development of profiling strategies to provide high resolution understanding of enzymes involved in bacterial infections remains an important need. These strategies help resolve enzyme mechanisms of actions and can guide therapeutic development. We have developed… read more here.
Keywords: based probe; c5a peptidase; peptidase; activity based ... See more keywords
Sulfated galactofucan from seaweed Padina tetrastromatica attenuates proteolytic enzyme dipeptidyl-peptidase-4: a potential anti-hyperglycemic lead
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2025802
Abstract: Abstract Dipeptidyl-peptidase-4 is a multifunctional ectoenzyme, which is implicated with hyperglycemic pathophysiology. Therefore, dipeptidyl-peptidase-4 inhibitors could be used as an attractive therapeutic strategy in blood-glucose homeostasis to attenuate the pathophysiologies of diabetes. A sulfated galactofucan… read more here.
Keywords: dipeptidyl peptidase; peptidase; padina tetrastromatica; seaweed padina ... See more keywords
The Evolutionary History of Peptidases Involved in the Processing of Organelle-Targeting Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac101
Abstract: Abstract Most of the proteins present in mitochondria and chloroplasts, the organelles acquired via endosymbiotic events, are encoded in the nucleus and translated into the cytosol. Most of such nuclear-encoded proteins are specifically recognized via… read more here.
Keywords: history; peptidase; involved processing; peptidases involved ... See more keywords