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   Articles with "peptidase" as a keyword



Acaciain peptidase: The first South American pollen peptidase potentially involved in respiratory allergy

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recommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.1837

Abstract: Acacia caven (Mol.) Molina pollen causes pollinosis in South America. The aim of this work was to isolate, purify, and characterize the proteolytic enzymes of A. caven pollen, and study their influence on allergy. A… read more here.

Keywords: acaciain peptidase; peptidase first; first south; peptidase ... See more keywords

Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-4

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recommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"

DOI: 10.1007/s10593-017-2062-4

Abstract: A novel series of pyridine-based derivatives was synthesized and evaluated for their inhibitory activity against dipeptidyl peptidase-4 (DPP4). 5-Aminomethyl-6-(2,4-dichlorophenyl)-4-[(1H-1,2,4-triazol-1-yl)methyl]pyridine-2-carboxylic acid was identified as a potent (IC50 0.57 nM) and selective DPP4 inhibitor (DPP8/DPP4 = 238).… read more here.

Keywords: phenylpyridine derivatives; biological evaluation; peptidase; synthesis phenylpyridine ... See more keywords

Signal peptidase I processed secretory signal sequences: Selection for and against specific amino acids at the second position of mature protein.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.01.044

Abstract: Signal peptides direct proteins from the cytoplasm to the periplasm. These N-terminal peptides are cleaved upon entry to the periplasm by either signal peptidase I, or signal peptidase II for lipoproteins. Signal peptidase I is… read more here.

Keywords: amino acids; position; signal peptidase; peptidase ... See more keywords

Fish skin gelatin hydrolysates produced by visceral peptidase and bovine trypsin: Bioactivity and stability.

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recommendations! Published in 2017 at "Food chemistry"

DOI: 10.1016/j.foodchem.2016.07.145

Abstract: The peptidase from the viscera of farmed giant catfish was used for producing gelatin hydrolysates (HG) and compared with those produced from commercial bovine trypsin (HB). The degree of hydrolysis (DH) observed suggests that proteolytic… read more here.

Keywords: visceral peptidase; gelatin hydrolysates; bovine trypsin; peptidase ... See more keywords
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General Strategy for Bioluminescence Sensing of Peptidase Activity In Vivo Based on Tumor-Targeting Probiotic.

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recommendations! Published in 2021 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.1c00093

Abstract: The abnormally expressed peptidases in human tissues are associated with many kinds of cancers. Monitoring of endogenous peptidase activity could allow us for pathophysiology elucidation and early clinical diagnosis. Herein, we developed a general strategy… read more here.

Keywords: sensing peptidase; peptidase activity; peptidase; strategy ... See more keywords

Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element.

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recommendations! Published in 2023 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00700

Abstract: The RiPP precursor recognition element (RRE) is a conserved domain found in many prokaryotic ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic gene clusters (BGCs). RREs bind with high specificity and affinity to a recognition… read more here.

Keywords: recognition; peptidase; rre; leader ... See more keywords

Structural and Functional Investigation of Putative Peptidase from Mycolicibacterium phlei: An Exclusive Endopeptidase among S9C Subfamily.

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recommendations! Published in 2025 at "Biochemistry"

DOI: 10.1021/acs.biochem.5c00047

Abstract: Peptidases of the prolyl oligopeptidase (S9 MEROPS) family play a pivotal role in various physiological processes. Among the S9 family, the S9C subfamily is remarkably diverse in exhibiting enzymatic activities such as acylaminoacyl peptidase, dipeptidyl… read more here.

Keywords: peptidase; putative peptidase; s9c subfamily; peptidase mycolicibacterium ... See more keywords
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Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-75288-y

Abstract: Dipeptidyl peptidase-4 inhibitors (DPP4i) are antidiabetic medications that prevent cleavage of incretin hormones by dipeptidyl peptidase-4 (DPP4). DPP4 is ubiquitously expressed, and its hepatic DPP4 expression is upregulated under non-alcoholic steatohepatitis (NASH) conditions. We investigated… read more here.

Keywords: trail receptor; peptidase; expression; mice ... See more keywords
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Accurate and sensitive detection of dipeptidyl peptidase-IV activity by liquid chromatography with fluorescence detection

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recommendations! Published in 2020 at "Analytical Methods"

DOI: 10.1039/c9ay02610j

Abstract: Dipeptidyl peptidase-IV (DPP-IV), an important prolyl-specific peptidase in the serine hydrolase family, hydrolyzes a large number of endogenous oligopeptides. In clinical studies, the detection of DPP-IV, especially the detection of its activity, is particularly important.… read more here.

Keywords: detection; fluorescence; method; dpp ... See more keywords

An activity-based probe targeting the streptococcal virulence factor C5a peptidase.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc01517j

Abstract: Development of profiling strategies to provide high resolution understanding of enzymes involved in bacterial infections remains an important need. These strategies help resolve enzyme mechanisms of actions and can guide therapeutic development. We have developed… read more here.

Keywords: based probe; c5a peptidase; peptidase; activity based ... See more keywords

Dipeptidyl peptidase IV inhibitors as a potential target for diabetes: patent review 2019 – present

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recommendations! Published in 2024 at "Expert Opinion on Therapeutic Patents"

DOI: 10.1080/13543776.2024.2446226

Abstract: ABSTRACT Introduction Dipeptidyl peptidase 4 enzyme has been identified as a potential target for the treatment of type 2 diabetes mellitus. DPP-IV is involved in the deactivation of two incretin hormones, namely glucose-dependent insulinotropic polypeptide… read more here.

Keywords: peptidase; dpp inhibitors; inhibitors potential; peptidase inhibitors ... See more keywords