Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Exhibits Antioxidant Mechanism for Abrogation of Cyclophosphamide-Induced Cardiac Damage and Oxidative Hepatorenal Toxicity in Rats.
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DOI: 10.1055/a-1842-7596
Abstract: Cyclophosphamide (CYP) is a potent DNA-interactive anticancer drug; however, its clinical drawbacks are chiefly associated with induction of oxidative multi-organ toxicity. Sitagliptin (STG) is an antidiabetic dipeptidyl peptidase-4 inhibitor drug with antioxidant efficacy. Herein, we… read more here.
Keywords: dipeptidyl peptidase; sitagliptin; peptidase inhibitor; toxicity ... See more keywords
Potential linkage between dipeptidyl peptidase‐4 inhibitor use and the risk of pancreatitis/pancreatic cancer
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DOI: 10.1111/jdi.13192
Abstract: Dipeptidyl peptidase (DPP)-4 inhibitors, a class of oral hypoglycemic agents, are widely used, especially in Asian populations, as they have been shown to be well-tolerated and to cause relatively few hypoglycemic events despite exerting a… read more here.
Keywords: linkage dipeptidyl; peptidase inhibitor; risk; potential linkage ... See more keywords
Association of dipeptidyl peptidase‐4 inhibitor use and risk of pancreatic cancer in individuals with diabetes in Japan
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DOI: 10.1111/jdi.13921
Abstract: This study was designed and carried out to investigate the association of dipeptidyl peptidase‐4 inhibitor (DPP‐4i) use with pancreatic cancer (PC) in individuals with diabetes in Japan. read more here.
Keywords: dipeptidyl peptidase; individuals diabetes; peptidase inhibitor; pancreatic cancer ... See more keywords
High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma
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DOI: 10.1186/s12931-020-01597-5
Abstract: Background Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown. Methods The expression levels of… read more here.
Keywords: peptidase inhibitor; serpin peptidase; expression; serpine2 expression ... See more keywords
Dipeptidyl peptidase-4 inhibitor compared with sulfonylurea in combination with metformin: cardiovascular and renal outcomes in a propensity-matched cohort study
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DOI: 10.1186/s12933-019-0835-z
Abstract: BackgroundTo determine the impact of dipeptidyl peptidase-4 inhibitor (DPP4i) on the risk of major cardiocerebrovascular and renal outcomes compared with sulfonylurea (SU) combined with metformin in patients with type 2 diabetes from a population-based cohort.MethodsFrom… read more here.
Keywords: peptidase inhibitor; compared sulfonylurea; renal outcomes; cohort ... See more keywords
In patients with type 2 diabetes the presence of Hashimoto's thyroiditis reduces the beneficial effect of dipeptidyl peptidase-4 inhibitor on plasma glucose control.
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DOI: 10.1507/endocrj.ej20-0620
Abstract: In this study, we compared the efficacy of a dipeptidyl peptidase-4 inhibitor (DPP4i) to improve glucose control in patients with type 2 diabetes mellitus (T2DM) with or without Hashimoto's thyroiditis (HT). First, we compared the… read more here.
Keywords: peptidase inhibitor; patients type; dpp4i; dipeptidyl peptidase ... See more keywords
Peptidase Inhibitor 15 (PI15) Regulates Chlamydial CPAF Activity
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DOI: 10.3389/fcimb.2018.00183
Abstract: Obligate intracellular pathogenic Chlamydia trachomatis express several serine proteases whose roles in chlamydial development and pathogenicity are not completely understood. The chlamydial protease CPAF is expressed during the replicative phase of the chlamydial developmental cycle… read more here.
Keywords: cpaf activity; peptidase inhibitor; pi15; inhibitor pi15 ... See more keywords
Nicotiana benthamiana Kunitz peptidase inhibitor-like protein involved in chloroplast-to-nucleus regulatory pathway in plant-virus interaction
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DOI: 10.3389/fpls.2022.1041867
Abstract: Plant viruses use a variety of strategies to infect their host. During infection, viruses cause symptoms of varying severity, which are often associated with altered leaf pigmentation due to structural and functional damage to chloroplasts… read more here.
Keywords: benthamiana kunitz; peptidase inhibitor; infection; nicotiana benthamiana ... See more keywords
Exogenous Nitric Oxide Alleviates the Damage Caused by Tomato Yellow Leaf Curl Virus in Tomato through Regulation of Peptidase Inhibitor Genes
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DOI: 10.3390/ijms232012542
Abstract: The tomato yellow leaf curl virus (TYLCV) is the causal agent of one of the most severe diseases affecting tomato growth; however, nitric oxide (NO) can mediate plant resistance. This study investigated the molecular mechanism… read more here.
Keywords: inhibitor genes; peptidase inhibitor; tomato; resistance ... See more keywords
Dipeptidyl Peptidase-4 Inhibitor-Related Bullous Pemphigoid: Clinical, Laboratory, and Histological Features, and Possible Pathogenesis
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DOI: 10.3390/ijms232214101
Abstract: Dipeptidyl peptidase-4 inhibitor (DPP4i) is a widely used antidiabetic agent. Emerging cases of DPP4i-associated bullous pemphigoid (DBP), whose pathogenesis remains unclear, have been reported. Thus, a retrospective study was conducted from January 2016 to June… read more here.
Keywords: dipeptidyl peptidase; bullous pemphigoid; peptidase inhibitor; clinical laboratory ... See more keywords