Engineering protein fragments via evolutionary and protein–protein interaction algorithms: de novo design of peptide inhibitors for FOF1‐ATP synthase
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13988
Abstract: Enzyme subunit interfaces have remarkable potential in drug design as both target and scaffold for their own inhibitors. We show an evolution‐driven strategy for the de novo design of peptide inhibitors targeting interfaces of the… read more here.
Keywords: protein; atp synthase; peptide; novo design ... See more keywords
Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700095
Abstract: Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to… read more here.
Keywords: peptide; cell; cell penetrating; protein aggregation ... See more keywords
Bioinspired Bromination Enables Extensible, Strain‐Stiffening Resilin Peptide Scaffolds with Tunable Degradation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202518804
Abstract: Short, bio‐inspired peptides hold promise for creating functional materials with unique structural and biochemical properties, yet their generally limited tunability of mechanical properties often restricts their utility. Inspired by Nature's strategic use of halogenation to… read more here.
Keywords: peptide scaffolds; strain stiffening; resilin; peptide ... See more keywords
Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100051
Abstract: The effectiveness of cancer immunotherapy is impaired by the dysfunctional vasculature of tumors. Created hypoxia zones and limited delivery of cytotoxic immune cells help to have immune resistance in tumor tissue. Structural and functional normalization… read more here.
Keywords: immune checkpoint; peptide; vessel normalization; tumor ... See more keywords
Well-defined Mannosylated Polymer for Peptide Vaccine Delivery with Enhanced Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101651
Abstract: Peptide-based cancer vaccines offer production and safety advantages but have had limited clinical success due to their intrinsic instability, rapid clearance, and low cellular uptake. Nanoparticle-based delivery vehicles can improve the in vivo stability and… read more here.
Keywords: peptide; antitumor immunity; well defined; delivery ... See more keywords
Peptide‐Based Cancer Vaccine Delivery via the STINGΔTM‐cGAMP Complex
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200905
Abstract: With the advent of bioinformatic tools in efficiently predicting neo‐antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to… read more here.
Keywords: peptide; cgamp; vaccine delivery; delivery ... See more keywords
Few‐Shot Identification of Active Therapeutic Peptide Networking with Gradient Dynamics against Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501753
Abstract: The treatment of osteosarcoma remains challenging due to limitations of chemotherapy. Anticancer peptides present a promising avenue as alternative therapeutic agents; however, they encounter significant drawbacks, including susceptibility to proteolytic degradation and constrained selectivity toward… read more here.
Keywords: cancer; gradient dynamics; tumor; peptide ... See more keywords
Mussel‐Glue Inspired Adhesives: A Study on the Relevance of l ‐Dopa and the Function of the Sequence at Nanomaterial‐Peptide Interfaces
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.201900501
Abstract: Mussel glue‐proteins undergo structural transitions at material interfaces to optimize adhesive surface contacts. Those intriguing structure responses are mimicked by a mussel‐glue mimetic peptide (HSY*SGWSPY*RSG (Y* = l‐Dopa)) that was previously selected by phage‐display to… read more here.
Keywords: peptide; full length; surface contacts; dopa ... See more keywords
Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204334
Abstract: Restoring sodium iodide symporter (NIS) expression and function remains a major challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient delivery of messenger RNA (mRNA) to manipulate protein expression, a lipid‐peptide‐mRNA (LPm)… read more here.
Keywords: mrna; peptide; thyroid cancer; lipid peptide ... See more keywords
A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202504710
Abstract: Antibody–drug conjugates (ADCs) have transformed cancer therapy but remain limited by their dependence on internalizing antigens, poor applicability to untargetable tumors, and susceptibility to drug resistance. Therefore, a modular antimicrobial‐peptide (AMP)‐based therapeutic system centered on… read more here.
Keywords: serum stable; antimicrobial peptide; peptide based; based delivery ... See more keywords
Immune Response of Zika prM Peptide PEG Conjugates in Peripheral Blood Mononuclear Cells
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology Journal"
DOI: 10.1002/biot.70140
Abstract: Despite the challenge in generating adequate immunogenicity, peptide‐based vaccines offer a significant benefit in terms of improving immunity when combined with conjugates. In previous studies, three computationally designed immunogenic peptides of the Zika prM protein… read more here.
Keywords: immune response; peptide; blood; peg ... See more keywords