Engineering protein fragments via evolutionary and protein–protein interaction algorithms: de novo design of peptide inhibitors for FOF1‐ATP synthase
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13988
Abstract: Enzyme subunit interfaces have remarkable potential in drug design as both target and scaffold for their own inhibitors. We show an evolution‐driven strategy for the de novo design of peptide inhibitors targeting interfaces of the… read more here.
Keywords: protein; atp synthase; peptide; novo design ... See more keywords
Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700095
Abstract: Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to… read more here.
Keywords: peptide; cell; cell penetrating; protein aggregation ... See more keywords
Bifunctional Therapeutic Peptide Assembled Nanoparticles Exerting Improved Activities of Tumor Vessel Normalization and Immune Checkpoint Inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100051
Abstract: The effectiveness of cancer immunotherapy is impaired by the dysfunctional vasculature of tumors. Created hypoxia zones and limited delivery of cytotoxic immune cells help to have immune resistance in tumor tissue. Structural and functional normalization… read more here.
Keywords: immune checkpoint; peptide; vessel normalization; tumor ... See more keywords
Well-defined Mannosylated Polymer for Peptide Vaccine Delivery with Enhanced Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101651
Abstract: Peptide-based cancer vaccines offer production and safety advantages but have had limited clinical success due to their intrinsic instability, rapid clearance, and low cellular uptake. Nanoparticle-based delivery vehicles can improve the in vivo stability and… read more here.
Keywords: peptide; antitumor immunity; well defined; delivery ... See more keywords
Peptide‐Based Cancer Vaccine Delivery via the STINGΔTM‐cGAMP Complex
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200905
Abstract: With the advent of bioinformatic tools in efficiently predicting neo‐antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to… read more here.
Keywords: peptide; cgamp; vaccine delivery; delivery ... See more keywords
Mussel‐Glue Inspired Adhesives: A Study on the Relevance of l ‐Dopa and the Function of the Sequence at Nanomaterial‐Peptide Interfaces
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.201900501
Abstract: Mussel glue‐proteins undergo structural transitions at material interfaces to optimize adhesive surface contacts. Those intriguing structure responses are mimicked by a mussel‐glue mimetic peptide (HSY*SGWSPY*RSG (Y* = l‐Dopa)) that was previously selected by phage‐display to… read more here.
Keywords: peptide; full length; surface contacts; dopa ... See more keywords
Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204334
Abstract: Restoring sodium iodide symporter (NIS) expression and function remains a major challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient delivery of messenger RNA (mRNA) to manipulate protein expression, a lipid‐peptide‐mRNA (LPm)… read more here.
Keywords: mrna; peptide; thyroid cancer; lipid peptide ... See more keywords
N‐methylation in amino acids and peptides: Scope and limitations
Sign Up to like & getrecommendations! Published in 2018 at "Biopolymers"
DOI: 10.1002/bip.23110
Abstract: Active pharmaceutical ingredients (APIs) can be divided into two types, namely chemical and biological entities. Traditionally, the former has been associated with the so‐called small molecules. The revival of peptides in pharmaceutical industry results from… read more here.
Keywords: peptide; amino acids; methylation amino; acids peptides ... See more keywords
Simplified AIP‐II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors
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DOI: 10.1002/cbic.201600516
Abstract: The bacterial pathogen Staphylococcus aureus controls many aspects of virulence by using the accessory gene regulator (agr) quorum sensing (QS) system. The agr system is activated by a macrocyclic peptide signal known as an autoinducing… read more here.
Keywords: staphylococcus aureus; peptide; agrc; simplified aip ... See more keywords
Rigid Peptide Macrocycles from On‐Resin Glaser Stapling
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800121
Abstract: Peptide macrocycles are widely utilized in the development of high affinity ligands, including stapled α‐helices. The linear rigidity of a 1,3‐diynyl linkage provides an optimal distance (7 Å) between β‐carbons of the i,i+4 amino acid side… read more here.
Keywords: peptide; peptide macrocycles; macrocycles resin; resin glaser ... See more keywords
Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800801
Abstract: Antimicrobial peptides (AMPs) kill bacteria by targeting their membranes through various mechanisms involving peptide assembly, often coupled with disorder‐to‐order structural transition. However, for several AMPs, similar conformational changes in cases in which small organic compounds… read more here.
Keywords: peptide; drug; cm15; function ... See more keywords